| Gene Symbol |
INCENP
|
| Entrez Gene |
3619
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
inner centromere protein antigens 135/155kDa
|
| Other Description |
binds and activates aurora-B and -C in vivo and in vitro|chromosomal passenger protein|inner centromere protein|inner centromere protein INCENP
|
| Swissprots |
A8MQD2 Q5Y192 Q9NQS7
|
| Accessions |
EAW74003 EAW74004 EAW74005 Q9NQS7 AF282265 AAF87584 AK056195 BAG51645 AK307633 AK310714 AW839685 AY714053 AAU04398 BC032678 BC098576 AAH98576 BC111732 CV569756 XM_006718533 XP_006718596 XM_011544995 XP_011543297 XM_011544996 XP_011543298 XM_011544997 XP_011543299 XM_011544998 XP_011543300 NM_001040694 NP_001035784 NM_020238 NP_064623
|
| Function |
Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Probably acts through association with AURKB or AURKC. Seems to bind directly to microtubules. Controls the kinetochore localization of BUB1. {ECO:0000269|PubMed:12925766, ECO:0000269|PubMed:15316025, ECO:0000269|PubMed:16760428}.
|
| Subcellular Location |
Chromosome, centromere. Cytoplasm, cytoskeleton, spindle. Nucleus. Chromosome, centromere, kinetochore. Note=Localizes to inner kinetochore. Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with AURKB at mitotic chromosomes.
|