| Gene Symbol |
FMO3
|
| Entrez Gene |
2328
|
| Alt Symbol |
FMOII, TMAU, dJ127D3.1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
flavin containing monooxygenase 3
|
| Other Description |
FMO 3|FMO II|FMO form 2|dimethylaniline monooxygenase [N-oxide-forming] 3|dimethylaniline oxidase 3|hepatic flavin-containing monooxygenase 3|hepatic flavin-containing monooxygenase-3|trimethylamine monooxygenase
|
| Swissprots |
Q8N5N5 Q14854 P31513 B2R816
|
| Accessions |
AAC51932 AAW65372 EAW90886 EAW90887 EAW90888 P31513 AI478384 AK223166 BAD96886 AK296105 BAH12258 AK298406 BAH12779 AK310785 AK313197 BAG36013 BC032016 AAH32016 BM453951 DQ892429 ABM83355 DQ895643 ABM86569 M83772 AAA86284 Z47552 CAA87632 XM_005245044 XP_005245101 XM_011509345 XP_011507647 XM_011509346 XP_011507648 NM_001002294 NP_001002294 NM_006894 NP_008825
|
| Function |
Involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. It N-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. Plays an important role in the metabolism of trimethylamine (TMA), via the production of TMA N-oxide (TMAO). Is also able to perform S-oxidation when acting on sulfide compounds.
|
| Subcellular Location |
Microsome membrane. Endoplasmic reticulum membrane.
|
| Tissue Specificity |
Liver.
|
| Top Pathways |
Drug metabolism - cytochrome P450
|
![Western Blot: FMO3 Overexpression Lysate (Adult Normal) [NBP2-08941] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for FMO3.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2803_FMO3%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-08941-img0001.jpg)