Gene Symbol | FMO3 |
---|---|
Entrez Gene | 2328 |
Alt Symbol | FMOII, TMAU, dJ127D3.1 |
Species | Human |
Gene Type | protein-coding |
Description | flavin containing monooxygenase 3 |
Other Description | FMO 3|FMO II|FMO form 2|dimethylaniline monooxygenase [N-oxide-forming] 3|dimethylaniline oxidase 3|hepatic flavin-containing monooxygenase 3|hepatic flavin-containing monooxygenase-3|trimethylamine monooxygenase |
Swissprots | Q8N5N5 Q14854 P31513 B2R816 |
Accessions | AAC51932 AAW65372 EAW90886 EAW90887 EAW90888 P31513 AI478384 AK223166 BAD96886 AK296105 BAH12258 AK298406 BAH12779 AK310785 AK313197 BAG36013 BC032016 AAH32016 BM453951 DQ892429 ABM83355 DQ895643 ABM86569 M83772 AAA86284 Z47552 CAA87632 XM_005245044 XP_005245101 XM_011509345 XP_011507647 XM_011509346 XP_011507648 NM_001002294 NP_001002294 NM_006894 NP_008825 |
Function | Involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. It N-oxygenates primary aliphatic alkylamines as well as secondary and tertiary amines. Plays an important role in the metabolism of trimethylamine (TMA), via the production of TMA N-oxide (TMAO). Is also able to perform S-oxidation when acting on sulfide compounds. |
Subcellular Location | Microsome membrane. Endoplasmic reticulum membrane. |
Tissue Specificity | Liver. |
Top Pathways | Drug metabolism - cytochrome P450 |
FMO3 CRISPR/Cas9 KO Plasmid (h) - sc-406605 from Santa Cruz Biotechnology
|
||||||||
FMO3 HDR Plasmid (h) - sc-406605-HDR from Santa Cruz Biotechnology
|
||||||||
FMO3 Double Nickase Plasmid (h) - sc-406605-NIC from Santa Cruz Biotechnology
|
||||||||
FMO3 Double Nickase Plasmid (h2) - sc-406605-NIC-2 from Santa Cruz Biotechnology
|
||||||||
FMO3 CRISPR Activation Plasmid (h) - sc-406605-ACT from Santa Cruz Biotechnology
|
||||||||
FMO3 CRISPR Activation Plasmid (h2) - sc-406605-ACT-2 from Santa Cruz Biotechnology
|
||||||||
FMO3 Lentiviral Activation Particles (h) - sc-406605-LAC from Santa Cruz Biotechnology
|
||||||||
FMO3 Lentiviral Activation Particles (h2) - sc-406605-LAC-2 from Santa Cruz Biotechnology
|
||||||||
FMO3 siRNA (h) - sc-72256 from Santa Cruz Biotechnology
|
||||||||
FMO3 shRNA Plasmid (h) - sc-72256-SH from Santa Cruz Biotechnology
|
||||||||
FMO3 shRNA (h) Lentiviral Particles - sc-72256-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EHU142881 from Sigma-Aldrich
|
||||||||
MISSION® esiRNA - EHU039311 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN1859 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1859 from Sigma-Aldrich
|
||||||||
MISSION® 3′UTR Lenti GoClone™ - HUTR03094 from Sigma-Aldrich
|
||||||||
FMO3 siRNA (Human) - CRH1631 from Cohesion Biosciences
|
||||||||
FMO3 - MBS8222815 from MyBioSource
|
||||||||
FMO3 CRISPR/Cas9 KO Plasmid (h2) - sc-406605-KO-2 from Santa Cruz Biotechnology
|
||||||||
FMO3 HDR Plasmid (h2) - sc-406605-HDR-2 from Santa Cruz Biotechnology
|
||||||||
Human FMO3 siRNA - orb262133 from Biorbyt
|
||||||||
FMO3 shRNA Plasmid (Human) - CHH1631 from Cohesion Biosciences
|