Gene Symbol | MEF2D |
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Entrez Gene | 4209 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | myocyte enhancer factor 2D |
Other Description | MADS box transcription enhancer factor 2, polypeptide D|myocyte-specific enhancer factor 2D |
Swissprots | D3DVC0 Q5T9U6 Q5T9U5 Q14814 Q14815 |
Accessions | AAA59579 CBX47582 EAW52948 EAW52950 EAW52951 EAW52952 Q14814 AB210005 BAE06087 AF086193 AK027180 AK056972 AK308641 BC018985 BC032479 AAH32479 BC040949 AAH40949 BC054520 AAH54520 BX640792 BX647226 DC377787 L16794 AAA93194 R42560 XM_005245169 XP_005245226 XM_005245170 XP_005245227 XM_006711330 XP_006711393 XM_006711332 XP_006711395 XM_006711333 XP_006711396 XM_006711334 XP_006711397 XM_011509569 XP_011507871 XM_011509570 XP_011507872 NM_001271629 NP_001258558 NM_005920 NP_005911 |
Function | Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle- specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00251, ECO:0000269|PubMed:12691662, ECO:0000269|PubMed:15743823}. Note=Translocated by HDAC4 to nuclear dots. |
Top Pathways | cGMP-PKG signaling pathway |
MEF-2D CRISPR/Cas9 KO Plasmid (h) - sc-403475 from Santa Cruz Biotechnology
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MEF-2D HDR Plasmid (h) - sc-403475-HDR from Santa Cruz Biotechnology
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MEF-2D Double Nickase Plasmid (h) - sc-403475-NIC from Santa Cruz Biotechnology
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MEF-2D Double Nickase Plasmid (h2) - sc-403475-NIC-2 from Santa Cruz Biotechnology
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MEF-2D CRISPR Activation Plasmid (h) - sc-403475-ACT from Santa Cruz Biotechnology
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MEF-2D CRISPR Activation Plasmid (h2) - sc-403475-ACT-2 from Santa Cruz Biotechnology
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MEF-2D Lentiviral Activation Particles (h) - sc-403475-LAC from Santa Cruz Biotechnology
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MEF-2D Lentiviral Activation Particles (h2) - sc-403475-LAC-2 from Santa Cruz Biotechnology
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MEF-2D siRNA (h) - sc-38064 from Santa Cruz Biotechnology
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MEF-2D shRNA Plasmid (h) - sc-38064-SH from Santa Cruz Biotechnology
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MEF-2D shRNA (h) Lentiviral Particles - sc-38064-V from Santa Cruz Biotechnology
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MEF2D RNAi - H00004209-R01 from Novus Biologicals
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MISSION® esiRNA - EHU145491 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13189 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13189 from Sigma-Aldrich
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MEF2D siRNA (Human) - CRH2861 from Cohesion Biosciences
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shRNA set against Human MEF2D (NM_005920.3) - SHH340211 from Creative biogene
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Human MEF2D siRNA - orb263363 from Biorbyt
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MEF2D shRNA Plasmid (Human) - CHH2861 from Cohesion Biosciences
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MEF2D miRNA 3'UTR clone - MiUTR4H-TG11720 from Creative biogene
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