Gene Symbol | RBBP5 |
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Entrez Gene | 5929 |
Alt Symbol | RBQ3, SWD1 |
Species | Human |
Gene Type | protein-coding |
Description | retinoblastoma binding protein 5 |
Other Description | RBBP-5|SWD1, Set1c WD40 repeat protein, homolog|retinoblastoma-binding protein 5|retinoblastoma-binding protein RBQ-3 |
Swissprots | Q8NDZ7 Q7Z6D8 Q15291 A8K272 |
Accessions | EAW91536 EAW91537 EAW91538 EAW91539 Q15291 AA235403 AK290137 BAF82826 AK296978 BAG59520 AK297540 BAG59939 AU099032 BC037284 AAH37284 BC053856 AAH53856 BC075059 AAH75059 BC075060 AAH75060 BG392257 BQ020418 CB133829 CD710496 DA797022 DQ891205 ABM82131 DQ894388 ABM85314 X85134 CAA59446 XM_005245398 XP_005245455 XM_005245401 XP_005245458 XM_006711477 XP_006711540 XM_011509833 XP_011508135 XM_011509834 XP_011508136 NM_001193272 NP_001180201 NM_001193273 NP_001180202 NM_005057 NP_005048 |
Function | In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (By similarity). As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3. Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. {ECO:0000250, ECO:0000269|PubMed:19556245}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:17355966}. |
Tissue Specificity | Ubiquitously expressed. |
RBQ-3 CRISPR/Cas9 KO Plasmid (h) - sc-418053 from Santa Cruz Biotechnology
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RBQ-3 HDR Plasmid (h) - sc-418053-HDR from Santa Cruz Biotechnology
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RBQ-3 Double Nickase Plasmid (h) - sc-418053-NIC from Santa Cruz Biotechnology
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RBQ-3 Double Nickase Plasmid (h2) - sc-418053-NIC-2 from Santa Cruz Biotechnology
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RBQ-3 CRISPR Activation Plasmid (h) - sc-418053-ACT from Santa Cruz Biotechnology
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RBQ-3 CRISPR Activation Plasmid (h2) - sc-418053-ACT-2 from Santa Cruz Biotechnology
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RBQ-3 Lentiviral Activation Particles (h) - sc-418053-LAC from Santa Cruz Biotechnology
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RBQ-3 Lentiviral Activation Particles (h2) - sc-418053-LAC-2 from Santa Cruz Biotechnology
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RBQ-3 siRNA (h) - sc-76373 from Santa Cruz Biotechnology
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RBQ-3 shRNA Plasmid (h) - sc-76373-SH from Santa Cruz Biotechnology
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RBQ-3 shRNA (h) Lentiviral Particles - sc-76373-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU024241 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18011 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18011 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10644 from Sigma-Aldrich
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RBBP5 siRNA (Human) - CRH4015 from Cohesion Biosciences
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RBBP5 - MBS8233599 from MyBioSource
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shRNA set against Human RBBP5 (NM_005057.3) - SHH390348 from Creative biogene
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Human RBBP5 siRNA - orb264517 from Biorbyt
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RBBP5 shRNA Plasmid (Human) - CHH4015 from Cohesion Biosciences
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RBBP5 miRNA 3'UTR clone - MiUTR3H-03566 from Creative biogene
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