KLK8

Gene Symbol KLK8
Entrez Gene 11202
Alt Symbol HNP, NP, NRPN, PRSS19, TADG14
Species Human
Gene Type protein-coding
Description kallikrein-related peptidase 8
Other Description kallikrein-8|ovasin|serine protease 19|serine protease TADG-14|tumor-associated differentially expressed gene 14 protein
Swissprots Q5V9X2 O60259 Q9UQ47 Q9NR68 Q9UIL9 Q9HCB3 Q5V9X1 Q9NR69 Q8IW69
Accessions AAD29574 AAF79144 AAF79145 AAG23254 AAG33361 AAT76913 AAT76914 AAT76915 AAT76916 AAT76917 AAT76918 AAT76919 AAT76920 AAT76921 AAT76922 AAT76923 AAT76924 AAT76925 AAT76926 AAT76927 AAT76928 AAT76929 AAT76930 AAT76931 AAT76932 AAT76933 AAT76934 AAT76935 AAT76936 AAT76937 AAT76938 BAA28676 BAA88684 EAW71962 EAW71963 EAW71964 O60259 AA320217 AA587273 AB008390 BAA82665 AB008927 BAA82666 AB009849 BAA28673 AF095742 AAD25979 AY359036 AAQ89395 BC040887 BM845575 EU350538 ACB05869 EU350539 ACB05870 HQ448625 ADQ33103 NM_001281431 NP_001268360 NM_007196 NP_009127 NM_144505 NP_653088 NM_144506 NP_653089 NM_144507 NP_653090 NR_104008
Function Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer- collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury. {ECO:0000269|PubMed:16337200}.
Subcellular Location Secreted {ECO:0000269|PubMed:17761692}. Cytoplasm {ECO:0000269|PubMed:17761692}. Note=Shows a cytoplasmic distribution in the keratinocytes.
Tissue Specificity Isoform 1 is predominantly expressed in the pancreas. Isoform 2 is expressed in adult brain and hippocampus. Isoform 1 and isoform 2 are found in fetal brain and placenta. Detected in salivary gland, uterus, thymus, breast, testis and kidney but not in spleen, liver, lung or normal ovarian tissue. Displays an 11.5-fold increase in Alzheimer disease hippocampus compared to controls and is overexpressed in some ovarian carcinomas. Expressed at low levels in normal skin while high levels are found in psoriasis vulgaris, seborrheic keratosis, lichen planus and squamous cell carcinoma skin samples. Expressed in the keratinocytes. {ECO:0000269|PubMed:11309326, ECO:0000269|PubMed:11522960, ECO:0000269|PubMed:12147714, ECO:0000269|PubMed:17761692}.

KLK8 (H-51) - sc-292340 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
KLK8 (H-51): sc-292340. Western blot analysis of KLK8 expression in Jurkat (A) and BT-20 (B) whole cell lysates.

KLK8 (W-19) - sc-67666 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

KLK8 (P-14) - sc-67664 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
KLK8 (P-14): sc-67664. Western blot analysis of KLK8 expression in non-transfected: sc-117752 (A) and human KLK8 transfected: sc-371800 (B) 293T whole cell lysates.

Anti-Kallikrein 8 antibody - ab197997 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue labeling Kallikrein 8 using ab197997 at 1/30 dilution.

Anti-Kallikrein 8 antibody - ab72800 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Kallikrein 8 antibody (ab72800) at 1/1000 dilutionLane 1 : Jurkat cells extractLane 2 : Jurkat cells extract with Cleaved peptide at 5 µgLysates/proteins at 5 µg per lane.

Anti-Kallikrein 8 antibody - ab123323 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Kallikrein 8 antibody (ab123323) at 1/100 dilutionLane 1 : 293 cell lysates non-transfected Lane 2 : 293 cell lysates transiently transfected with Kallikren 8Lysates/proteins at 2 µg per lane.

Anti-Kallikrein 8 antibody [ EPR5752(2)] - ab150395 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5752(2)
All lanes : Anti-Kallikrein 8 antibody [ EPR5752(2)] (ab150395) at 1/1000 dilutionLane 1 : Jurkat cell lysateLane 2 : Human fetal brain cell lysateLane 3 : A431 cell lysateLane 4 : HeLa cell lysateLysates/proteins at 10 µg per lane.SecondaryHRP labelled goat anti-rabbit

Anti-Kallikrein 8 antibody [1H6] - ab140490 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1H6
Immunofluorescent analysis of COS7 cells transiently transfected with pCMV6-ENTRY Kallikrein 8, labelling Kallikrein 8 with ab140490 at 1/100 dilution.

Anti-Kallikrein 8 antibody [MM0434-6G15] - ab89661 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone MM0434-6G15

Anti-Kallikrein 8 antibody - Catalytic domain - ab40954 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Kallikrein 8 antibody - Catalytic domain (ab40954) at 1/1000 dilutionLane 1 : Kallikrein 8 at 0.05 µgLane 2 : Kallikrein 8 at 0.01 µgLane 3 : Kallikrein 8 at 0.001 µg

Anti-Kallikrein 8 antibody - Kallikrein loop - ab28310 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Kallikrein 8 antibody - Kallikrein loop (ab28310) at 1/1000 dilutionLane 1 : Kallikrein 8 at 0.05 µgLane 2 : Kallikrein 8 at 0.01 µgLane 3 : Kallikrein 8 at 0.001 µg

Anti-KLK8 / Kallikrein 8 Antibody (aa33-260, clone 1G9) - LS-C338523 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1G9
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY KLK8 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-KLK8.

Anti-KLK8 / Kallikrein 8 Antibody (clone 1H3) - LS-C338062 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1H3
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY KLK8 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-KLK8.

Anti-KLK8 / Kallikrein 8 Antibody (aa33-260, clone 3A12) - LS-C338511 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3A12
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY KLK8 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-KLK8.

Anti-KLK8 / Kallikrein 8 Antibody (aa33-260, clone 6D6) - LS-C338682 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 6D6
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY KLK8 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-KLK8.

Anti-KLK8 / Kallikrein 8 Antibody (aa33-260, clone 3G5) - LS-C336351 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3G5
IHC of paraffin-embedded Human skin tissue using anti-KLK8 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

Anti-KLK8 / Kallikrein 8 Antibody (aa33-260, clone 11F7) - LS-C336354 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 11F7
IHC of paraffin-embedded Human skin tissue using anti-KLK8 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

Anti-KLK8 / Kallikrein 8 Antibody (aa33-260, clone 11C3) - LS-C336815 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 11C3
IHC of paraffin-embedded Human skin tissue using anti-KLK8 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120°C for 3min).

Anti-KLK8 / Kallikrein 8 Antibody (clone 6F4) - LS-C338061 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 6F4
Anti-KLK8 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY KLK8.

Anti-KLK8 / Kallikrein 8 Antibody (clone 1A9) - LS-C338057 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1A9
Anti-KLK8 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY KLK8.

Anti-KLK8 / Kallikrein 8 Antibody - LS-C125844 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-KLK8 / Kallikrein 8 Antibody (aa14-63) - LS-C121094 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from Jurkat cells, treated with etoposide 25 uM 24h, using Neuropsin (Cleaved-Val33) Antibody. The lane on the right is treated with the synthesized peptide.

Anti-KLK8 / Kallikrein 8 Antibody (clone 2C10) - LS-C174697 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2C10
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY KLK8 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-KLK8.

Anti-KLK8 / Kallikrein 8 Antibody (clone 8F2) - LS-C174700 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 8F2
Anti-KLK8 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY KLK8.

Anti-KLK8 / Kallikrein 8 Antibody (clone 1A10) - LS-C174698 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1A10
Anti-KLK8 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY KLK8.
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