KLK8

Gene Symbol	KLK8
Entrez Gene	11202
Alt Symbol	HNP, NP, NRPN, PRSS19, TADG14
Species	Human
Gene Type	protein-coding
Description	kallikrein-related peptidase 8
Other Description	kallikrein-8|ovasin|serine protease 19|serine protease TADG-14|tumor-associated differentially expressed gene 14 protein
Swissprots	Q5V9X2 O60259 Q9UQ47 Q9NR68 Q9UIL9 Q9HCB3 Q5V9X1 Q9NR69 Q8IW69
Accessions	AAD29574 AAF79144 AAF79145 AAG23254 AAG33361 AAT76913 AAT76914 AAT76915 AAT76916 AAT76917 AAT76918 AAT76919 AAT76920 AAT76921 AAT76922 AAT76923 AAT76924 AAT76925 AAT76926 AAT76927 AAT76928 AAT76929 AAT76930 AAT76931 AAT76932 AAT76933 AAT76934 AAT76935 AAT76936 AAT76937 AAT76938 BAA28676 BAA88684 EAW71962 EAW71963 EAW71964 O60259 AA320217 AA587273 AB008390 BAA82665 AB008927 BAA82666 AB009849 BAA28673 AF095742 AAD25979 AY359036 AAQ89395 BC040887 BM845575 EU350538 ACB05869 EU350539 ACB05870 HQ448625 ADQ33103 NM_001281431 NP_001268360 NM_007196 NP_009127 NM_144505 NP_653088 NM_144506 NP_653089 NM_144507 NP_653090 NR_104008
Function	Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer- collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury. {ECO:0000269|PubMed:16337200}.
Subcellular Location	Secreted {ECO:0000269|PubMed:17761692}. Cytoplasm {ECO:0000269|PubMed:17761692}. Note=Shows a cytoplasmic distribution in the keratinocytes.
Tissue Specificity	Isoform 1 is predominantly expressed in the pancreas. Isoform 2 is expressed in adult brain and hippocampus. Isoform 1 and isoform 2 are found in fetal brain and placenta. Detected in salivary gland, uterus, thymus, breast, testis and kidney but not in spleen, liver, lung or normal ovarian tissue. Displays an 11.5-fold increase in Alzheimer disease hippocampus compared to controls and is overexpressed in some ovarian carcinomas. Expressed at low levels in normal skin while high levels are found in psoriasis vulgaris, seborrheic keratosis, lichen planus and squamous cell carcinoma skin samples. Expressed in the keratinocytes. {ECO:0000269|PubMed:11309326, ECO:0000269|PubMed:11522960, ECO:0000269|PubMed:12147714, ECO:0000269|PubMed:17761692}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human KLK8 / Kallikrein 8 ELISA Kit (Competitive EIA) - LS-F4528 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 225.3 pg/ml Range 617.28-50000 pg/ml

Rat KLK8 / Kallikrein 8 ELISA Kit (Sandwich ELISA) - LS-F11892 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.625 ng/ml Range 617.28-50000 pg/ml

Kallikrein 8, hK 8, Human, ELISA Kit - CSB-E09249h from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Kallikrein-8, KLK8, Human, ELISA Kit - E0690h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.78-50 ng/mL

Kallikrein 8, KLK8, Human, ELISA Kit - E-EL-H1468 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.469 Range 0.781-50ng/mL

Kallikrein 8, KLK8, Rabbit, ELISA Kit - E-EL-RB1977 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Kallikrein 8, KLK8, Chicken, ELISA Kit - E-EL-Ch0870 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t

Kallikrein 8, KLK8, Porcine, ELISA Kit - E-EL-P1603 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Kallikrein 8, KLK8, Monkey, ELISA Kit - E-EL-MK0954 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Human KLK8 ELISA Kit - HK0082 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine KLK8 ELISA Kit - AK0082 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

kallikrein-related peptidase 8, ELISA Kit - MBS704816 from MyBioSource Category ELISA Kit Prices $250.00, $550.00, $795.00, $2,890.00, $5,465.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Human KLK8(Kallikrein 8) ELISA Kit - E-EL-H1468 from Elabscience Category ELISA Kit Sensitivity 0.47 ng/mL Range 0.78—50 ng/mL

Human KLK8 (Kallikrein 8) CLIA Kit - E-CL-H0947 from Elabscience Category CLIA Kit Sensitivity 0.09 ng/mL Range Average Recovery (%)

Kallikrein 8, ELISA Kit - MBS027904 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kallikrein 8, ELISA Kit - MBS064262 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kallikrein 8, ELISA Kit - MBS741128 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kallikrein 8, ELISA Kit - MBS049420 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kallikrein 8, ELISA Kit - MBS012048 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kallikrein 8, ELISA Kit - MBS735516 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kallikrein 8, ELISA Kit - MBS725802 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kallikrein 8, ELISA Kit - MBS033862 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kallikrein 8, ELISA Kit - MBS106071 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kallikrein 8, ELISA Kit - MBS030049 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kallikrein 8, ELISA Kit - MBS738663 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

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