| Gene Symbol |
KLK8
|
| Entrez Gene |
11202
|
| Alt Symbol |
HNP, NP, NRPN, PRSS19, TADG14
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
kallikrein-related peptidase 8
|
| Other Description |
kallikrein-8|ovasin|serine protease 19|serine protease TADG-14|tumor-associated differentially expressed gene 14 protein
|
| Swissprots |
Q5V9X2 O60259 Q9UQ47 Q9NR68 Q9UIL9 Q9HCB3 Q5V9X1 Q9NR69 Q8IW69
|
| Accessions |
AAD29574 AAF79144 AAF79145 AAG23254 AAG33361 AAT76913 AAT76914 AAT76915 AAT76916 AAT76917 AAT76918 AAT76919 AAT76920 AAT76921 AAT76922 AAT76923 AAT76924 AAT76925 AAT76926 AAT76927 AAT76928 AAT76929 AAT76930 AAT76931 AAT76932 AAT76933 AAT76934 AAT76935 AAT76936 AAT76937 AAT76938 BAA28676 BAA88684 EAW71962 EAW71963 EAW71964 O60259 AA320217 AA587273 AB008390 BAA82665 AB008927 BAA82666 AB009849 BAA28673 AF095742 AAD25979 AY359036 AAQ89395 BC040887 BM845575 EU350538 ACB05869 EU350539 ACB05870 HQ448625 ADQ33103 NM_001281431 NP_001268360 NM_007196 NP_009127 NM_144505 NP_653088 NM_144506 NP_653089 NM_144507 NP_653090 NR_104008
|
| Function |
Serine protease which is capable of degrading a number of proteins such as casein, fibrinogen, kininogen, fibronectin and collagen type IV. Also cleaves L1CAM in response to increased neural activity. Induces neurite outgrowth and fasciculation of cultured hippocampal neurons. Plays a role in the formation and maturation of orphan and small synaptic boutons in the Schaffer- collateral pathway, regulates Schaffer-collateral long-term potentiation in the hippocampus and is required for memory acquisition and synaptic plasticity. Involved in skin desquamation and keratinocyte proliferation. Plays a role in the secondary phase of pathogenesis following spinal cord injury. {ECO:0000269|PubMed:16337200}.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:17761692}. Cytoplasm {ECO:0000269|PubMed:17761692}. Note=Shows a cytoplasmic distribution in the keratinocytes.
|
| Tissue Specificity |
Isoform 1 is predominantly expressed in the pancreas. Isoform 2 is expressed in adult brain and hippocampus. Isoform 1 and isoform 2 are found in fetal brain and placenta. Detected in salivary gland, uterus, thymus, breast, testis and kidney but not in spleen, liver, lung or normal ovarian tissue. Displays an 11.5-fold increase in Alzheimer disease hippocampus compared to controls and is overexpressed in some ovarian carcinomas. Expressed at low levels in normal skin while high levels are found in psoriasis vulgaris, seborrheic keratosis, lichen planus and squamous cell carcinoma skin samples. Expressed in the keratinocytes. {ECO:0000269|PubMed:11309326, ECO:0000269|PubMed:11522960, ECO:0000269|PubMed:12147714, ECO:0000269|PubMed:17761692}.
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