TICAM2

Gene Symbol TICAM2
Entrez Gene 353376
Alt Symbol MyD88-4, TICAM-2, TIRAP3, TIRP, TRAM
Species Human
Gene Type protein-coding
Description toll-like receptor adaptor molecule 2
Other Description NF-kappa-B-activating protein 502|TIR domain-containing adapter molecule 2|TRIF-related adaptor molecule|cytoplasmic adaptor|putative NF-kappa-B-activating protein 502|toll-like receptor adaptor protein 3|toll/interleukin-1 receptor (TIR) domain-containing adapter protein
Swissprots B3Y698 Q86XR7 Q6JUT2
Accessions EAW48960 Q86XR7 AB002444 AB091054 BAC98397 AB097022 BAC77375 AB109098 BAC98399 AB446491 BAG55268 AY232653 AAO74498 AY304582 AAQ97431 BC109265 AAI09266 BC109266 AAI09267 BX956265 CA441688 CD638761 DA092564 DA899189 DA992598 NM_021649 NP_067681
Function Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response.
Subcellular Location Isoform 1: Cytoplasm. Golgi apparatus. Cell membrane. Endoplasmic reticulum. Early endosome membrane. Late endosome membrane. Note=Localized to the plasma membrane as a result of myristoylation. Phosphorylation on Ser-16 leads to its depletion from the membrane. Upon LPS stimulation colcoalizes with isoform 2 in late endosomes.
Tissue Specificity Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas Isoform 2 is ubiquitously expressed (at lower levels than isoform 1). {ECO:0000269|PubMed:12721283, ECO:0000269|PubMed:14519765, ECO:0000269|PubMed:19412184}.
Top Pathways Toll-like receptor signaling pathway, Pertussis

TICAM-2 (E-2) - sc-376076 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TICAM-2 (E-2): sc-376076. Western blot analysis of TICAM-2 expression in LPS treated U-937 whole cell lysate.

TICAM-2 (G-6) - sc-376356 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TICAM-2 (G-6): sc-376356. Western blot analysis of TICAM-2 expression in PC-3 whole cell lysate.

TICAM-2 (F-12) - sc-34743 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TICAM-2 (H-85) - sc-67061 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TICAM-2 (H-85): sc-67061. Immunoperoxidase staining of formalin fixed, paraffin-embedded human seminal vesicle tissue showing cytoplasmic staining of glandular cells.

TICAM-2 (V-13) - sc-34748 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
TICAM-2 (V-13): sc-34748. Western blot analysis of TICAM-2 expression in U-937 (A), LPS-treated U-937 (B), PC-3 (C) and OV-90 (D) whole cell lysates.

TICAM-2 (I-12) - sc-34744 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-TICAM2 / TRAM Antibody (C-Terminus) IHC-plus™ - LS-B713 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-TICAM2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B713 concentration 10 ug/ml.

Anti-TICAM2 / TRAM Antibody (aa2-29) - LS-C10826 from LifeSpan Bioscience

Prices $405.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-TICAM2 / TRAM Antibody (C-Terminus) - LS-C10827 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TICAM2 / TRAM Antibody (C-Terminus) - LS-C10828 from LifeSpan Bioscience

Prices $435.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TICAM2 / TRAM Antibody - LS-C18612 from LifeSpan Bioscience

Prices $265.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-TICAM2 / TRAM Antibody (aa18-32) - LS-C39774 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-TICAM2 / TRAM Antibody (aa1-232) - LS-C39775 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-TICAM2 / TRAM Antibody (aa18-32) - LS-C147864 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-TICAM2 / TRAM Antibody (C-Terminus) - LS-C124698 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-TICAM2 / TRAM Antibody (aa87-103) - LS-C148195 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-TICAM2 / TRAM Antibody (aa2-20) - LS-C149010 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-TICAM2 / TRAM Antibody (aa12-41, APC) - LS-C271477 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TICAM2 / TRAM Antibody (aa12-41, AP) - LS-C271478 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TICAM2 / TRAM Antibody (aa12-41, Biotin) - LS-C271479 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TICAM2 / TRAM Antibody (aa12-41, FITC) - LS-C271480 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TICAM2 / TRAM Antibody - LS-C26886 from LifeSpan Bioscience

Prices $360.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of TIRP in human (A), mouse (B), and rat (C) kidney cell lysates with TIRP antibody (C2) at 1 g/ml.

Anti-TICAM2 / TRAM Antibody (aa12-41, Azide-free, HRP) - LS-C271481 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TICAM2 / TRAM Antibody (aa12-41, PE) - LS-C271483 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TICAM2 / TRAM Antibody (aa22-205, Biotin) - LS-C300028 from LifeSpan Bioscience

Prices $425.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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