| Gene Symbol |
TICAM2
|
| Entrez Gene |
353376
|
| Alt Symbol |
MyD88-4, TICAM-2, TIRAP3, TIRP, TRAM
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
toll-like receptor adaptor molecule 2
|
| Other Description |
NF-kappa-B-activating protein 502|TIR domain-containing adapter molecule 2|TRIF-related adaptor molecule|cytoplasmic adaptor|putative NF-kappa-B-activating protein 502|toll-like receptor adaptor protein 3|toll/interleukin-1 receptor (TIR) domain-containing adapter protein
|
| Swissprots |
B3Y698 Q86XR7 Q6JUT2
|
| Accessions |
EAW48960 Q86XR7 AB002444 AB091054 BAC98397 AB097022 BAC77375 AB109098 BAC98399 AB446491 BAG55268 AY232653 AAO74498 AY304582 AAQ97431 BC109265 AAI09266 BC109266 AAI09267 BX956265 CA441688 CD638761 DA092564 DA899189 DA992598 NM_021649 NP_067681
|
| Function |
Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response.
|
| Subcellular Location |
Isoform 1: Cytoplasm. Golgi apparatus. Cell membrane. Endoplasmic reticulum. Early endosome membrane. Late endosome membrane. Note=Localized to the plasma membrane as a result of myristoylation. Phosphorylation on Ser-16 leads to its depletion from the membrane. Upon LPS stimulation colcoalizes with isoform 2 in late endosomes.
|
| Tissue Specificity |
Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas Isoform 2 is ubiquitously expressed (at lower levels than isoform 1). {ECO:0000269|PubMed:12721283, ECO:0000269|PubMed:14519765, ECO:0000269|PubMed:19412184}.
|
| Top Pathways |
Toll-like receptor signaling pathway, Pertussis
|
