| Gene Symbol | TICAM2 |
|---|---|
| Entrez Gene | 353376 |
| Alt Symbol | MyD88-4, TICAM-2, TIRAP3, TIRP, TRAM |
| Species | Human |
| Gene Type | protein-coding |
| Description | toll-like receptor adaptor molecule 2 |
| Other Description | NF-kappa-B-activating protein 502|TIR domain-containing adapter molecule 2|TRIF-related adaptor molecule|cytoplasmic adaptor|putative NF-kappa-B-activating protein 502|toll-like receptor adaptor protein 3|toll/interleukin-1 receptor (TIR) domain-containing adapter protein |
| Swissprots | B3Y698 Q86XR7 Q6JUT2 |
| Accessions | EAW48960 Q86XR7 AB002444 AB091054 BAC98397 AB097022 BAC77375 AB109098 BAC98399 AB446491 BAG55268 AY232653 AAO74498 AY304582 AAQ97431 BC109265 AAI09266 BC109266 AAI09267 BX956265 CA441688 CD638761 DA092564 DA899189 DA992598 NM_021649 NP_067681 |
| Function | Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response. |
| Subcellular Location | Isoform 1: Cytoplasm. Golgi apparatus. Cell membrane. Endoplasmic reticulum. Early endosome membrane. Late endosome membrane. Note=Localized to the plasma membrane as a result of myristoylation. Phosphorylation on Ser-16 leads to its depletion from the membrane. Upon LPS stimulation colcoalizes with isoform 2 in late endosomes. |
| Tissue Specificity | Expressed in spleen, prostate, testis, uterus, small intestine, colon, peripheral blood leukocytes, heart, placenta, lung, liver, skeletal muscle, and pancreas Isoform 2 is ubiquitously expressed (at lower levels than isoform 1). {ECO:0000269|PubMed:12721283, ECO:0000269|PubMed:14519765, ECO:0000269|PubMed:19412184}. |
| Top Pathways | Toll-like receptor signaling pathway, Pertussis |