Gene Symbol | KLF17 |
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Entrez Gene | 128209 |
Alt Symbol | ZNF393, Zfp393 |
Species | Human |
Gene Type | protein-coding |
Description | Kruppel-like factor 17 |
Other Description | Krueppel-like factor 17|novel zinc-finger protein|zinc finger protein 393 |
Swissprots | Q86VQ7 Q8N805 Q5JT82 |
Accessions | CBH30658 EAX07052 EAX07053 Q5JT82 AK097479 BAC05070 AK308458 BC031250 BC035408 BC049844 AAH49844 DB046781 HG491971 HG491972 HG491973 HG491974 HG491975 HG491977 LK938585 XM_005270465 XP_005270522 XM_011540700 XP_011539002 XM_011540701 XP_011539003 XM_011540702 XP_011539004 XM_011540703 XP_011539005 XM_011540704 XP_011539006 NM_173484 NP_775755 |
Function | Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000305}. |
KLF17 CRISPR/Cas9 KO Plasmid (h) - sc-414317 from Santa Cruz Biotechnology
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KLF17 HDR Plasmid (h) - sc-414317-HDR from Santa Cruz Biotechnology
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KLF17 Double Nickase Plasmid (h) - sc-414317-NIC from Santa Cruz Biotechnology
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KLF17 Double Nickase Plasmid (h2) - sc-414317-NIC-2 from Santa Cruz Biotechnology
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KLF17 CRISPR Activation Plasmid (h) - sc-414317-ACT from Santa Cruz Biotechnology
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KLF17 CRISPR Activation Plasmid (h2) - sc-414317-ACT-2 from Santa Cruz Biotechnology
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KLF17 Lentiviral Activation Particles (h) - sc-414317-LAC from Santa Cruz Biotechnology
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KLF17 Lentiviral Activation Particles (h2) - sc-414317-LAC-2 from Santa Cruz Biotechnology
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KLF17 siRNA (h) - sc-88294 from Santa Cruz Biotechnology
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KLF17 shRNA Plasmid (h) - sc-88294-SH from Santa Cruz Biotechnology
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KLF17 shRNA (h) Lentiviral Particles - sc-88294-V from Santa Cruz Biotechnology
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KLF17 RNAi - H00128209-R01 from Novus Biologicals
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MISSION® esiRNA - EHU013281 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11251 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11251 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR12809 from Sigma-Aldrich
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KLF17 siRNA (Human) - CRJ4944 from Cohesion Biosciences
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shRNA set against Human Klf17 (NM_173484.3) - SHH325795 from Creative biogene
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shRNA set against Human KLF17(NM_173484.3) - SHL199622 from Creative biogene
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Human KLF17 siRNA - orb275445 from Biorbyt
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KLF17 shRNA Plasmid (Human) - CHJ4944 from Cohesion Biosciences
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KLF17 miRNA 3'UTR clone - MiUTR1H-05357 from Creative biogene
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