SMG5

Gene Symbol	SMG5
Entrez Gene	23381
Alt Symbol	EST1B, LPTS-RP1, LPTSRP1, SMG-5
Species	Human
Gene Type	protein-coding
Description	SMG5 nonsense mediated mRNA decay factor
Other Description	EST1 telomerase component homolog B|EST1-like protein B|Est1p-like protein B|LPTS interacting protein|LPTS-interacting protein|RP11-54H19.7|ever shorter telomeres 1B|hSMG-5|protein SMG5|smg-5 homolog, nonsense mediated mRNA decay factor
Swissprots	Q659C7 Q96IJ7 Q8IY09 Q5QJE7 D3DVB7 Q8IXC0 Q9UPR3
Accessions	EAW52973 EAW52974 Q9UPR3 AB029012 BAA83041 AB085691 BAC53623 AK025988 AK026395 AK027486 BAB55147 AK092183 AL137738 CAH56374 AY168922 AAO17582 AY336728 AAQ84301 BC007292 BC007453 AAH07453 BC038296 AAH38296 CR933677 CT000143 XM_005245049 XP_005245106 XM_011509361 XP_011507663 XM_011509362 XP_011507664 XR_921762 NM_015327 NP_056142
Function	Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity. {ECO:0000269|PubMed:17053788}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:14636577}. Nucleus {ECO:0000269|PubMed:14636577}. Note=Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm. Detected in cytoplasmic mRNA decay bodies.
Tissue Specificity	Ubiquitous. {ECO:0000269|PubMed:12699629, ECO:0000269|PubMed:14636577}.
Top Pathways	mRNA surveillance pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SMG5 (N-16) - sc-50979 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

SMG5 (P-14) - sc-50980 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-SMG5 antibody - ab33033 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SMG5 antibody - ab100798 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SMG5 antibody [EPR3503(2)] - ab129107 from Abcam Prices $387.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR3503(2)

Anti-SMG5 Antibody (aa912-941, AP) - LS-C217628 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SMG5 Antibody (aa912-941, APC) - LS-C217629 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SMG5 Antibody (aa912-941, Biotin) - LS-C217630 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SMG5 Antibody (aa912-941, Azide-free, HRP) - LS-C217632 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SMG5 Antibody (aa912-941, FITC) - LS-C217631 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SMG5 Antibody (aa912-941, PE) - LS-C217633 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SMG5 Antibody (aa600-650) - LS-C289518 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SMG5 Antibody (aa400-450) - LS-C289517 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SMG5 Antibody (aa912-941) - LS-C159041 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-SMG5 Antibody (aa912-941) - LS-C325205 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-SMG5 Antibody (N-Terminus) - LS-C111619 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SMG5 Antibody (Internal, clone EPR3503(2)) - LS-C152476 from LifeSpan Bioscience Prices $485.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR3503(2)

SMG5 Antibody - NBP1-56778 from Novus Biologicals Prices $139.00, $329.00 Sizes 20 µl, 100 µl Host Rabbit Clonality Polyclonal

SMG5 Antibody - NBP1-47272 from Novus Biologicals Prices $359.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SMG5 Antibody - H00023381-B01 from Novus Biologicals Prices $349.00 Sizes 50 µl Host Mouse Clonality Polyclonal

ANTI-SMG5(C-TERMINAL) antibody produced in rabbit - SAB1305269 from Sigma-Aldrich Prices $326.00 Sizes 40 tst Host Rabbit Clonality Polyclonal

SMG5 antibody - N-terminal region (ARP55229_P050) - ARP55229_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

SMG5-Antibody-C-term - AP19361b from Abgent, a WuXi AppTec company Prices $99.00, $295.00 Sizes 80 µl, 400 µl Host Rabbit Clonality Polyclonal

SMG5 Antibody - C-terminal region (OAAB14946) - OAAB14946 from Aviva Systems Biology Prices $289.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

SMG5 antibody - 70R-20404 from Fitzgerald Prices $375.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

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