| Gene Symbol |
SMG5
|
| Entrez Gene |
23381
|
| Alt Symbol |
EST1B, LPTS-RP1, LPTSRP1, SMG-5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SMG5 nonsense mediated mRNA decay factor
|
| Other Description |
EST1 telomerase component homolog B|EST1-like protein B|Est1p-like protein B|LPTS interacting protein|LPTS-interacting protein|RP11-54H19.7|ever shorter telomeres 1B|hSMG-5|protein SMG5|smg-5 homolog, nonsense mediated mRNA decay factor
|
| Swissprots |
Q659C7 Q96IJ7 Q8IY09 Q5QJE7 D3DVB7 Q8IXC0 Q9UPR3
|
| Accessions |
EAW52973 EAW52974 Q9UPR3 AB029012 BAA83041 AB085691 BAC53623 AK025988 AK026395 AK027486 BAB55147 AK092183 AL137738 CAH56374 AY168922 AAO17582 AY336728 AAQ84301 BC007292 BC007453 AAH07453 BC038296 AAH38296 CR933677 CT000143 XM_005245049 XP_005245106 XM_011509361 XP_011507663 XM_011509362 XP_011507664 XR_921762 NM_015327 NP_056142
|
| Function |
Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity. {ECO:0000269|PubMed:17053788}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:14636577}. Nucleus {ECO:0000269|PubMed:14636577}. Note=Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm. Detected in cytoplasmic mRNA decay bodies.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:12699629, ECO:0000269|PubMed:14636577}.
|
| Top Pathways |
mRNA surveillance pathway
|