SMG5

Gene Symbol SMG5
Entrez Gene 23381
Alt Symbol EST1B, LPTS-RP1, LPTSRP1, SMG-5
Species Human
Gene Type protein-coding
Description SMG5 nonsense mediated mRNA decay factor
Other Description EST1 telomerase component homolog B|EST1-like protein B|Est1p-like protein B|LPTS interacting protein|LPTS-interacting protein|RP11-54H19.7|ever shorter telomeres 1B|hSMG-5|protein SMG5|smg-5 homolog, nonsense mediated mRNA decay factor
Swissprots Q659C7 Q96IJ7 Q8IY09 Q5QJE7 D3DVB7 Q8IXC0 Q9UPR3
Accessions EAW52973 EAW52974 Q9UPR3 AB029012 BAA83041 AB085691 BAC53623 AK025988 AK026395 AK027486 BAB55147 AK092183 AL137738 CAH56374 AY168922 AAO17582 AY336728 AAQ84301 BC007292 BC007453 AAH07453 BC038296 AAH38296 CR933677 CT000143 XM_005245049 XP_005245106 XM_011509361 XP_011507663 XM_011509362 XP_011507664 XR_921762 NM_015327 NP_056142
Function Plays a role in nonsense-mediated mRNA decay. Does not have RNase activity by itself. Promotes dephosphorylation of UPF1. Together with SMG7 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Necessary for TERT activity. {ECO:0000269|PubMed:17053788}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:14636577}. Nucleus {ECO:0000269|PubMed:14636577}. Note=Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm. Detected in cytoplasmic mRNA decay bodies.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:12699629, ECO:0000269|PubMed:14636577}.
Top Pathways mRNA surveillance pathway

SMG5 CRISPR/Cas9 KO Plasmid (h) - sc-406989 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMG5 HDR Plasmid (h) - sc-406989-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMG5 Double Nickase Plasmid (h) - sc-406989-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMG5 Double Nickase Plasmid (h2) - sc-406989-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMG5 CRISPR Activation Plasmid (h) - sc-406989-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMG5 CRISPR Activation Plasmid (h2) - sc-406989-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMG5 Lentiviral Activation Particles (h) - sc-406989-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMG5 Lentiviral Activation Particles (h2) - sc-406989-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SMG5 siRNA (h) - sc-61567 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SMG5 shRNA Plasmid (h) - sc-61567-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SMG5 shRNA (h) Lentiviral Particles - sc-61567-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU101781 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19790 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19790 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09480 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr09480

SMG5 siRNA (Human) - CRH8225 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SMG5 - MBS8241016 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SMG5 (NM_015327.2) - SHH413412 from Creative biogene

Category siRNA
Species Reactivities Human

Human SMG5 siRNA - orb268727 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SMG5 shRNA Plasmid (Human) - CHH8225 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SMG5 miRNA 3'UTR clone - MiUTR3H-11573 from Creative biogene

Species Reactivities Human
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