| Gene Symbol |
CAPN6
|
| Entrez Gene |
827
|
| Alt Symbol |
CANPX, CAPNX, CalpM, DJ914P14.1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
calpain 6
|
| Other Description |
calpain-6|calpain-like protease X-linked|calpamodulin
|
| Swissprots |
D3DUY7 Q9Y6Q1 Q9UJA8 Q9UEQ1
|
| Accessions |
AAV41896 CAB70568 EAX02650 EAX02651 Q9Y6Q1 AA368247 AF029232 AAB86605 AJ000388 CAA04051 AK300340 BAG62085 AK312701 BAG35579 BC000730 AAH00730 DA863483 DQ891851 ABM82777 DQ895041 ABM85967 L32067 NM_014289 NP_055104
|
| Function |
Microtubule-stabilizing protein that may be involved in the regulation of microtubule dynamics and cytoskeletal organization. May act as a regulator of RAC1 activity through interaction with ARHGEF2 to control lamellipodial formation and cell mobility. Does not seem to have protease activity as it has lost the active site residues (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, perinuclear region {ECO:0000269|PubMed:17210638}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:17210638}. Note=During mitose associated with the mitotic spindle. At telophase colocalized to the midbody spindle.
|
| Tissue Specificity |
Expressed only in placenta.
|
![Western Blot: Calpain 6 Overexpression Lysate (Adult Normal) [NBL1-08682] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Calpain 6.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1647_Calpain%25206%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-08682-img0002.jpg)