| Gene Symbol |
RAB27A
|
| Entrez Gene |
5873
|
| Alt Symbol |
GS2, HsT18676, RAB27, RAM
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RAB27A, member RAS oncogene family
|
| Other Description |
GTP-binding protein Ram|rab-27|ras-related protein Rab-27A
|
| Swissprots |
Q9Y5U3 O00195 Q6FI40 P51159 Q9UIR9
|
| Accessions |
AAD47629 AAL39097 EAW77476 EAW77477 EAW77478 EAW77479 P51159 AF125393 AAD43049 AF498953 AAM21101 AK312836 BAG35690 AV661679 BC078139 BC107680 AAI07681 BC132800 AAI32801 BC136423 AAI36424 BM014705 CA398159 CA437806 CR457076 CAG33357 CR536496 CAG38735 CR541693 CAG46494 DA182503 DA553342 HQ258130 ADR82884 U38654 AAC50271 U57094 AAC51195 XM_005254576 XP_005254633 XM_011521852 XP_011520154 XM_011521853 XP_011520155 XM_011521854 XP_011520156 XM_011521855 XP_011520157 XM_011521856 XP_011520158 NM_004580 NP_004571 NM_183234 NP_899057 NM_183235 NP_899058 NM_183236 NP_899059
|
| Function |
Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. {ECO:0000269|PubMed:18812475}.
|
| Subcellular Location |
Membrane; Lipid-anchor. Melanosome. Late endosome. Lysosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Localizes to endosomal exocytic vesicles.
|
| Tissue Specificity |
Found in all the examined tissues except in brain. Low expression was found in thymus, kidney, muscle and placenta. Detected in melanocytes, and in most tumor cell lines examined. Expressed in cytotoxic T-lymphocytes (CTL) and mast cells. {ECO:0000269|PubMed:15548590}.
|