| Gene Symbol | LECT1 |
|---|---|
| Entrez Gene | 11061 |
| Alt Symbol | BRICD3, CHM-I, CHM1, MYETS1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | leukocyte cell derived chemotaxin 1 |
| Other Description | BRICHOS domain containing 3|chondromodulin I|chondromodulin-1|chondromodulin-I|leukocyte cell-derived chemotaxin 1|multiple myeloma tumor suppressor 1 |
| Swissprots | Q5TAM4 Q9UM18 O75829 Q8TAY6 |
| Accessions | AAC98971 BAA77384 EAW52047 EAW52048 O75829 AB005999 BAA86262 AB006000 BAA33443 AY368652 AAQ72693 BC025659 AAH25659 CR541910 CAG46708 XM_006719761 XP_006719824 XM_011534897 XP_011533199 XM_011534898 XP_011533200 XM_011534899 XP_011533201 XM_011534900 XP_011533202 NM_001011705 NP_001011705 NM_007015 NP_008946 |
| Function | Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization. {ECO:0000269|PubMed:16980969}. |
| Subcellular Location | Chondromodulin-1: Secreted, extracellular space, extracellular matrix. Note=Accumulated in the inter- territorial matrix of cartilage. |
| Tissue Specificity | Detected in cartilage and cardiac valves (at protein level). Detected in the laminae fibrosa, spongiosa and ventricularis layers of normal cardiac valves (at protein level). Expression is decreased cardiac valves of patients with valvular heart disease (at protein level). Weakly expressed in chondrosarcoma. {ECO:0000269|PubMed:16980969}. |