| Gene Symbol | LECT1 |
|---|---|
| Entrez Gene | 11061 |
| Alt Symbol | BRICD3, CHM-I, CHM1, MYETS1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | leukocyte cell derived chemotaxin 1 |
| Other Description | BRICHOS domain containing 3|chondromodulin I|chondromodulin-1|chondromodulin-I|leukocyte cell-derived chemotaxin 1|multiple myeloma tumor suppressor 1 |
| Swissprots | Q5TAM4 Q9UM18 O75829 Q8TAY6 |
| Accessions | AAC98971 BAA77384 EAW52047 EAW52048 O75829 AB005999 BAA86262 AB006000 BAA33443 AY368652 AAQ72693 BC025659 AAH25659 CR541910 CAG46708 XM_006719761 XP_006719824 XM_011534897 XP_011533199 XM_011534898 XP_011533200 XM_011534899 XP_011533201 XM_011534900 XP_011533202 NM_001011705 NP_001011705 NM_007015 NP_008946 |
| Function | Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization. {ECO:0000269|PubMed:16980969}. |
| Subcellular Location | Chondromodulin-1: Secreted, extracellular space, extracellular matrix. Note=Accumulated in the inter- territorial matrix of cartilage. |
| Tissue Specificity | Detected in cartilage and cardiac valves (at protein level). Detected in the laminae fibrosa, spongiosa and ventricularis layers of normal cardiac valves (at protein level). Expression is decreased cardiac valves of patients with valvular heart disease (at protein level). Weakly expressed in chondrosarcoma. {ECO:0000269|PubMed:16980969}. |
ChM-1 CRISPR/Cas9 KO Plasmid (h) - sc-403523 from Santa Cruz Biotechnology
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ChM-1 HDR Plasmid (h) - sc-403523-HDR from Santa Cruz Biotechnology
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ChM-1 Double Nickase Plasmid (h) - sc-403523-NIC from Santa Cruz Biotechnology
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ChM-1 Double Nickase Plasmid (h2) - sc-403523-NIC-2 from Santa Cruz Biotechnology
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ChM-1 CRISPR Activation Plasmid (h) - sc-403523-ACT from Santa Cruz Biotechnology
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ChM-1 CRISPR Activation Plasmid (h2) - sc-403523-ACT-2 from Santa Cruz Biotechnology
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ChM-1 Lentiviral Activation Particles (h) - sc-403523-LAC from Santa Cruz Biotechnology
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ChM-1 Lentiviral Activation Particles (h2) - sc-403523-LAC-2 from Santa Cruz Biotechnology
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ChM-1 siRNA (h) - sc-43279 from Santa Cruz Biotechnology
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ChM-1 shRNA Plasmid (h) - sc-43279-SH from Santa Cruz Biotechnology
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ChM-1 shRNA (h) Lentiviral Particles - sc-43279-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU015911 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11633 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11633 from Sigma-Aldrich
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LECT1 siRNA (Human) - CRH7559 from Cohesion Biosciences
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ChM-1 CRISPR/Cas9 KO Plasmid (h2) - sc-403523-KO-2 from Santa Cruz Biotechnology
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ChM-1 HDR Plasmid (h2) - sc-403523-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human LECT1 (NM_007015.2) - SHH329431 from Creative biogene
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shRNA set against Human LECT1(NM_001011705.1) - SHG175447 from Creative biogene
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shRNA set against Human LECT1(NM_007015.2) - SHG175465 from Creative biogene
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LECT1 shRNA Plasmid (Human) - CHH7559 from Cohesion Biosciences
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LECT1 miRNA 3'UTR clone - MiUTR1H-05629 from Creative biogene
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LECT1 miRNA 3'UTR clone - MiUTR1H-05630 from Creative biogene
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