| Gene Symbol |
DCTN3
|
| Entrez Gene |
11258
|
| Alt Symbol |
DCTN-22, DCTN22
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
dynactin 3 (p22)
|
| Other Description |
dynactin complex subunit 22 kDa subunit|dynactin light chain|dynactin subunit 3
|
| Swissprots |
Q5T8G3 Q5T1I5 A6NII7 Q5T1I7 Q9BPU8 B2RBM5 O75935
|
| Accessions |
EAW58439 EAW58440 EAW58441 EAW58442 O75935 AF082513 AAC61280 AK055199 AK091661 BAC03716 AK314730 BAG37272 AW953496 BC000319 AAH00319 BC003004 AAH03004 BC107697 AAI07698 BG715167 BI596981 BI837796 CN257020 CR541889 CAG46687 DA212054 DQ891980 ABM82906 EU176665 ABW03466 NM_001281425 NP_001268354 NM_001281426 NP_001268355 NM_001281427 NP_001268356 NM_007234 NP_009165 NM_024348 NP_077324
|
| Function |
Together with dynein may be involved in spindle assembly and cytokinesis. {ECO:0000269|PubMed:9722614}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:9722614}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:9722614}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:9722614}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:9722614}. Cleavage furrow {ECO:0000269|PubMed:9722614}. Midbody {ECO:0000269|PubMed:9722614}. Note=Localizes to punctate cytoplasmic structures and to the centrosome during interphase, and to kinetochores and to spindle poles throughout mitosis. Colocalizes with dynein to the cleavage furrow and to midbody of dividing cells.
|
| Tissue Specificity |
Ubiquitously expressed. Highly expressed in muscle and pancreas and detected at lower levels in brain. {ECO:0000269|PubMed:9722614}.
|