| Gene Symbol | DCTN3 |
|---|---|
| Entrez Gene | 11258 |
| Alt Symbol | DCTN-22, DCTN22 |
| Species | Human |
| Gene Type | protein-coding |
| Description | dynactin 3 (p22) |
| Other Description | dynactin complex subunit 22 kDa subunit|dynactin light chain|dynactin subunit 3 |
| Swissprots | Q5T8G3 Q5T1I5 A6NII7 Q5T1I7 Q9BPU8 B2RBM5 O75935 |
| Accessions | EAW58439 EAW58440 EAW58441 EAW58442 O75935 AF082513 AAC61280 AK055199 AK091661 BAC03716 AK314730 BAG37272 AW953496 BC000319 AAH00319 BC003004 AAH03004 BC107697 AAI07698 BG715167 BI596981 BI837796 CN257020 CR541889 CAG46687 DA212054 DQ891980 ABM82906 EU176665 ABW03466 NM_001281425 NP_001268354 NM_001281426 NP_001268355 NM_001281427 NP_001268356 NM_007234 NP_009165 NM_024348 NP_077324 |
| Function | Together with dynein may be involved in spindle assembly and cytokinesis. {ECO:0000269|PubMed:9722614}. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:9722614}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:9722614}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:9722614}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:9722614}. Cleavage furrow {ECO:0000269|PubMed:9722614}. Midbody {ECO:0000269|PubMed:9722614}. Note=Localizes to punctate cytoplasmic structures and to the centrosome during interphase, and to kinetochores and to spindle poles throughout mitosis. Colocalizes with dynein to the cleavage furrow and to midbody of dividing cells. |
| Tissue Specificity | Ubiquitously expressed. Highly expressed in muscle and pancreas and detected at lower levels in brain. {ECO:0000269|PubMed:9722614}. |
Dynactin 3 CRISPR/Cas9 KO Plasmid (h) - sc-408827 from Santa Cruz Biotechnology
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Dynactin 3 HDR Plasmid (h) - sc-408827-HDR from Santa Cruz Biotechnology
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Dynactin 3 Double Nickase Plasmid (h) - sc-408827-NIC from Santa Cruz Biotechnology
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Dynactin 3 Double Nickase Plasmid (h2) - sc-408827-NIC-2 from Santa Cruz Biotechnology
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Dynactin 3 CRISPR Activation Plasmid (h) - sc-408827-ACT from Santa Cruz Biotechnology
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Dynactin 3 CRISPR Activation Plasmid (h2) - sc-408827-ACT-2 from Santa Cruz Biotechnology
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Dynactin 3 Lentiviral Activation Particles (h) - sc-408827-LAC from Santa Cruz Biotechnology
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Dynactin 3 Lentiviral Activation Particles (h2) - sc-408827-LAC-2 from Santa Cruz Biotechnology
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Dynactin 3 siRNA (h) - sc-92863 from Santa Cruz Biotechnology
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Dynactin 3 shRNA Plasmid (h) - sc-92863-SH from Santa Cruz Biotechnology
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Dynactin 3 shRNA (h) Lentiviral Particles - sc-92863-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU125601 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN7005 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7005 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02108 from Sigma-Aldrich
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DCTN3 siRNA (Human) - CRH7717 from Cohesion Biosciences
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DCTN3 - MBS8217785 from MyBioSource
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shRNA set against Human DCTN3 (NM_007234.3) - SHH275381 from Creative biogene
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shRNA set against Human DCTN3(NM_007234.3) - SHG224731 from Creative biogene
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shRNA set against Human DCTN3(NM_024348.2) - SHG224763 from Creative biogene
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Human DCTN3 siRNA - orb268219 from Biorbyt
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DCTN3 shRNA Plasmid (Human) - CHH7717 from Cohesion Biosciences
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DCTN3 miRNA 3'UTR clone - MiUTR1H-02699 from Creative biogene
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DCTN3 miRNA 3'UTR clone - MiUTR1H-02700 from Creative biogene
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