| Gene Symbol |
RAPGEF5
|
| Entrez Gene |
9771
|
| Alt Symbol |
GFR, MR-GEF, REPAC
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Rap guanine nucleotide exchange factor (GEF) 5
|
| Other Description |
M-Ras-regulated GEF|M-Ras-regulated Rap GEF|guanine nucleotide exchange factor for Rap1|rap guanine nucleotide exchange factor 5|related to Epac
|
| Swissprots |
Q92565 A4D140 Q8IXU5
|
| Accessions |
EAL24270 EAW93746 Q92565 AA732485 AA815190 AA890636 AK295859 BAG58663 AL833195 CAI46177 AW511225 BC039203 AAH39203 BF512545 BP349215 D87467 BAA13406 DN996625 W56891 XM_005249914 XP_005249971 XM_005249916 XP_005249973 XM_011515652 XP_011513954 NM_012294 NP_036426
|
| Function |
Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation. {ECO:0000269|PubMed:10777494, ECO:0000269|PubMed:10934204}.
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
Widely expressed with highest levels in brain.
|
| Top Pathways |
Rap1 signaling pathway
|