| Gene Symbol |
REV1
|
| Entrez Gene |
51455
|
| Alt Symbol |
REV1L
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
REV1, polymerase (DNA directed)
|
| Other Description |
AIBP80|DNA repair protein REV1|REV1 homolog|REV1- like|alpha integrin-binding protein 80|rev1-like terminal deoxycytidyl transferase
|
| Swissprots |
Q9C0J4 Q53SI7 O95941 Q9NUP2 Q9UBZ9
|
| Accessions |
AAW82434 AAY24314 EAX01860 EAX01861 EAX01862 EAX01863 Q9UBZ9 AB047646 BAB21441 AF151538 AAF06731 AF206019 AAF18986 AF357886 AAK43708 AJ131720 CAB38231 AK002087 BAA92079 AK025176 AK307719 BC037734 AAH37734 BC130411 AAI30412 BM683065 XM_011511336 XP_011509638 XM_011511337 XP_011509639 XM_011511338 XP_011509640 XM_011511339 XP_011509641 XM_011511340 XP_011509642 XM_011511341 XP_011509643 XR_427092 XR_922941 NM_001037872 NP_001032961 NM_016316 NP_057400
|
| Function |
Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. {ECO:0000269|PubMed:10536157, ECO:0000269|PubMed:10760286, ECO:0000269|PubMed:11278384, ECO:0000269|PubMed:11485998, ECO:0000269|PubMed:22266823}.
|
| Subcellular Location |
Nucleus {ECO:0000305}.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:10536157, ECO:0000269|PubMed:11278384, ECO:0000269|PubMed:11485998}.
|
| Top Pathways |
Fanconi anemia pathway
|
![Western Blot: REV1 Overexpression Lysate (Adult Normal) [NBL1-15290] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for REV1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3873_REV1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15290-img0002.jpg)