Gene Symbol | REV1 |
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Entrez Gene | 51455 |
Alt Symbol | REV1L |
Species | Human |
Gene Type | protein-coding |
Description | REV1, polymerase (DNA directed) |
Other Description | AIBP80|DNA repair protein REV1|REV1 homolog|REV1- like|alpha integrin-binding protein 80|rev1-like terminal deoxycytidyl transferase |
Swissprots | Q9C0J4 Q53SI7 O95941 Q9NUP2 Q9UBZ9 |
Accessions | AAW82434 AAY24314 EAX01860 EAX01861 EAX01862 EAX01863 Q9UBZ9 AB047646 BAB21441 AF151538 AAF06731 AF206019 AAF18986 AF357886 AAK43708 AJ131720 CAB38231 AK002087 BAA92079 AK025176 AK307719 BC037734 AAH37734 BC130411 AAI30412 BM683065 XM_011511336 XP_011509638 XM_011511337 XP_011509639 XM_011511338 XP_011509640 XM_011511339 XP_011509641 XM_011511340 XP_011509642 XM_011511341 XP_011509643 XR_427092 XR_922941 NM_001037872 NP_001032961 NM_016316 NP_057400 |
Function | Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents. {ECO:0000269|PubMed:10536157, ECO:0000269|PubMed:10760286, ECO:0000269|PubMed:11278384, ECO:0000269|PubMed:11485998, ECO:0000269|PubMed:22266823}. |
Subcellular Location | Nucleus {ECO:0000305}. |
Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:10536157, ECO:0000269|PubMed:11278384, ECO:0000269|PubMed:11485998}. |
Top Pathways | Fanconi anemia pathway |
REV1 CRISPR/Cas9 KO Plasmid (h) - sc-402251 from Santa Cruz Biotechnology
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REV1 HDR Plasmid (h) - sc-402251-HDR from Santa Cruz Biotechnology
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REV1 Double Nickase Plasmid (h) - sc-402251-NIC from Santa Cruz Biotechnology
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REV1 Double Nickase Plasmid (h2) - sc-402251-NIC-2 from Santa Cruz Biotechnology
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REV1 CRISPR Activation Plasmid (h) - sc-402251-ACT from Santa Cruz Biotechnology
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REV1 CRISPR Activation Plasmid (h2) - sc-402251-ACT-2 from Santa Cruz Biotechnology
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REV1 Lentiviral Activation Particles (h) - sc-402251-LAC from Santa Cruz Biotechnology
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REV1 Lentiviral Activation Particles (h2) - sc-402251-LAC-2 from Santa Cruz Biotechnology
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REV1 siRNA (h) - sc-38232 from Santa Cruz Biotechnology
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REV1 shRNA Plasmid (h) - sc-38232-SH from Santa Cruz Biotechnology
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REV1 shRNA (h) Lentiviral Particles - sc-38232-V from Santa Cruz Biotechnology
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REV1 RNAi - H00051455-R01 from Novus Biologicals
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MISSION® esiRNA - EHU144351 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18157 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18157 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06618 from Sigma-Aldrich
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REV1 siRNA (Human) - CRH9774 from Cohesion Biosciences
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REV1 - MBS8218747 from MyBioSource
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shRNA set against Human REV1 (NM_016316.2) - SHH392096 from Creative biogene
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shRNA set against Human REV1(NM_016316.2) - SHR176280 from Creative biogene
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shRNA set against Human REV1(NM_001037872.1) - SHR176602 from Creative biogene
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shRNA set against Human REV1(NM_016316.2) - SHR176620 from Creative biogene
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REV1 shRNA Plasmid (Human) - CHH9774 from Cohesion Biosciences
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REV1 miRNA 3'UTR clone - MiUTR1H-08744 from Creative biogene
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REV1 miRNA 3'UTR clone - MiUTR1H-08745 from Creative biogene
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