| Gene Symbol |
PIK3R3
|
| Entrez Gene |
8503
|
| Alt Symbol |
p55, p55-GAMMA, p55PIK
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
|
| Other Description |
PI3-kinase regulatory subunit gamma|PI3-kinase subunit p55-gamma|PI3K regulatory subunit gamma|phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma|phosphatidylinositol 3-kinase regulatory subunit gamma|phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 3 (p55, gamma)|phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (p55, gamma)|ptdIns-3-kinase regulatory subunit p55-gamma
|
| Swissprots |
Q5T4P1 O60482 B2R9C1 Q92569 Q5T4P2 D3DQ12
|
| Accessions |
EAX06943 EAX06944 EAX06945 EAX06946 EAX06947 Q92569 AF028785 AAC39696 AK302049 BAG63440 AK304713 BAG65477 AK313726 BAG36468 BC005381 AAH05381 BC021622 AAH21622 BC094768 BX507484 BX537388 CAD97630 CR749649 CAH18443 D88532 BAA13636 DB047431 DQ891789 ABM82715 DQ894971 ABM85897 EU832448 ACE87620 EU832531 ACE86933 U90907 Y13809 CAB52195 NM_001114172 NP_001107644 NM_001303427 NP_001290356 NM_001303428 NP_001290357 NM_001303429 NP_001290358 NM_003629 NP_003620
|
| Function |
Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.
|
| Tissue Specificity |
Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle.
|
| Top Pathways |
Apoptosis, VEGF signaling pathway, Focal adhesion, Toll-like receptor signaling pathway, Jak-STAT signaling pathway
|