PIK3R3

Gene Symbol PIK3R3
Entrez Gene 8503
Alt Symbol p55, p55-GAMMA, p55PIK
Species Human
Gene Type protein-coding
Description phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
Other Description PI3-kinase regulatory subunit gamma|PI3-kinase subunit p55-gamma|PI3K regulatory subunit gamma|phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma|phosphatidylinositol 3-kinase regulatory subunit gamma|phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 3 (p55, gamma)|phosphoinositide-3-kinase, regulatory subunit, polypeptide 3 (p55, gamma)|ptdIns-3-kinase regulatory subunit p55-gamma
Swissprots Q5T4P1 O60482 B2R9C1 Q92569 Q5T4P2 D3DQ12
Accessions EAX06943 EAX06944 EAX06945 EAX06946 EAX06947 Q92569 AF028785 AAC39696 AK302049 BAG63440 AK304713 BAG65477 AK313726 BAG36468 BC005381 AAH05381 BC021622 AAH21622 BC094768 BX507484 BX537388 CAD97630 CR749649 CAH18443 D88532 BAA13636 DB047431 DQ891789 ABM82715 DQ894971 ABM85897 EU832448 ACE87620 EU832531 ACE86933 U90907 Y13809 CAB52195 NM_001114172 NP_001107644 NM_001303427 NP_001290356 NM_001303428 NP_001290357 NM_001303429 NP_001290358 NM_003629 NP_003620
Function Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1.
Tissue Specificity Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle.
Top Pathways Apoptosis, VEGF signaling pathway, Focal adhesion, Toll-like receptor signaling pathway, Jak-STAT signaling pathway

Phospho-PI3 Kinase p85 (Tyr458)/p55 (Tyr199) Antibody - 4228 from Cell Signaling Technology

Prices $109.00, $287.00, $678.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots), 300 µl (30 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from NIH/3T3-Src cells, untreated or treated with lambda phosphatase and from C2C12 cells, untreated or treated with H2O2, using Phospho-PI3 Kinase p85 (Tyr458)/p55 (Tyr199) Antibody.

PI3 Kinase p55 (D2B3) Rabbit mAb - 11889 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D2B3
Western blot analysis of extracts from MDA-MB-453, Hs578T, and ZR-75-1 cells using PI3 Kinase p55 (D2B3) Rabbit mAb (upper) or β-Actin (D6A8) Rabbit mAb #8457 (lower).

PI 3-kinase p55γ (E-9) - sc-376615 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PI 3-kinase p55γ (E-9): sc-376615. Western blot analysis of PI 3-kinase p55γ expression in SK-N-MC (A) and MCF7 (B) whole cell lysates.

PI 3-kinase p55γ (N-13) - sc-48644 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PI 3-kinase p55γ (N-13): sc-48644. Western blot analysis of PI 3-kinase p55γ expression in SK-N-MC (A), MCF7 (B) and BE (2)-M17 (C) whole cell lysates.

Anti-PI 3 Kinase p55 gamma antibody - ab76460 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-PI 3 Kinase p55 gamma antibody (ab76460) at 1 µg/ml + Recombinant tagged PI 3 Kinase p55 gamma fragment at 0.1 µgSecondaryGoat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/5000 dilution

Anti-PI 3 Kinase p55 gamma antibody [EPR18415] - ab186612 from Abcam

Prices $99.00, $347.00
Sizes 10 µl, 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR18415
Immunofluorescent analysis of 4% paraformaldehyde-fixed, 0.1% Triton X-100 permeabilized SH-SY5Y (Human neuroblastoma from bone marrow cells) cells labeling PI 3 Kinase p55 gamma with ab186612 at 1/1000 dilution, followed by Goat anti-rabbit IgG (Alexa Fluor® 488) (ab150077) secondary antibody at 1/500 dilution (green).Confocal image showing cytoplasmic staining on SH-SY5Y cells. The nuclear counter stain is DAPI (blue).Tubulin is detected with ab7291 (anti-Tubulin mouse mAb) at 1/1000 dilution and ab150120 (AlexaFluor®594 Goat anti-Mouse secondary) at 1/500 dilution (red).The negative controls are as follows:-ve control 1: ab186612 at 1/1000 dilution followed by ab150120 (AlexaFluor®594 Goat anti-Mouse secondary) at 1/500 dilution.-ve control 2: ab7291 (anti-Tubulin mouse mAb) at 1/1000 dilution followed by ab150077 (Alexa Fluor®488 Goat Anti-Rabbit IgG H&L) at 1/500 dilution.

Anti-PI 3 Kinase p85 gamma antibody - Carboxyterminal end - ab37825 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-PI 3 Kinase p85 gamma antibody - Carboxyterminal end (ab37825) + Mouse brain tissue lysate

Anti-PIK3R3 / p85 Gamma Antibody - LS-C38242 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-PIK3R3 / p85 Gamma Antibody (aa251-378) - LS-C126132 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-PIK3R3 / p85 Gamma Antibody - LS-C90210 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-PIK3R3 / p85 Gamma Antibody (aa324-353, AP) - LS-C266372 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIK3R3 / p85 Gamma Antibody (aa324-353, APC) - LS-C266375 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIK3R3 / p85 Gamma Antibody (aa324-353, Biotin) - LS-C266376 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIK3R3 / p85 Gamma Antibody (aa324-353, Azide-free, HRP) - LS-C266378 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIK3R3 / p85 Gamma Antibody (aa324-353, FITC) - LS-C266377 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIK3R3 / p85 Gamma Antibody (aa324-353, PE) - LS-C266379 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIK3R3 / p85 Gamma Antibody (aa324-353) - LS-C324065 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PIK3R3 / p85 Gamma Antibody (aa201-250) - LS-C80063 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Transfected 293T cell lysate. Antibody concentration: 5.0 ug/ml. Gel concentration: 12%.

Anti-PIK3R3 / p85 Gamma Antibody - LS-C332696 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using PIK3R3 antibody.

Anti-PIK3R3 / p85 Gamma Antibody (aa175-224) - LS-C206160 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PIK3R3 / p85 Gamma antibody Western Blot of MCF7. Antibody dilution: 1 ug/ml.

Anti-PIK3R3 / p85 Gamma Antibody (aa192-427) - LS-C185915 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded SAS xenograft using PIK3R3 antibody at 1:500 dilution.

Anti-PIK3R3 / p85 Gamma Antibody (aa316-346) - LS-C99851 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with PIK3R3 antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

PI 3-Kinase p55 gamma Antibody (668619) [Unconjugated] - MAB6638 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 668619
Western blot shows lysates of HEK293 human embryonic kidney cell line, NIH‑3T3 mouse embryonic fibroblast cell line, and L6 rat myoblast cell line. PVDF Membrane was probed with 1 µg/mL of Human/Mouse/Rat PI 3‑Kinase p55 gamma  Monoclonal Antibody (Catalog # MAB6638) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for p55 gamma  at approximately 55 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

PI 3-Kinase p55 gamma Antibody - AF5734 from Novus Biologicals

Prices $99.00, $329.00
Sizes 25 µg, 100 µg
Host Goat
Clonality Polyclonal
Western blot shows lysates of SH-SY5Y human neuroblastoma cell line, C2C12 mouse myoblast cell line, and Rat-2 rat embryonic fibroblast cell line. PVDF membrane was probed with 1 µg/mL of Human/Mouse/Rat PI 3-Kinase p55 gamma  Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5734) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). A specific band was detected for PI 3-Kinase p55 gamma at approximately 55 to 57 kDa (as indicated). This experiment was conducted using Immunoblot Buffer Group 1.

PIK3R3 Antibody - NBP1-32636 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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