| Gene Symbol |
RBM22
|
| Entrez Gene |
55696
|
| Alt Symbol |
Cwc2, ZC3H16, fSAP47
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RNA binding motif protein 22
|
| Other Description |
RNA-binding motif protein 22|functional spliceosome-associated protein 47|pre-mRNA-splicing factor RBM22|zinc finger CCCH domain-containing protein 16
|
| Swissprots |
O95607 B4DLI9 A6NDM5 Q9NW64
|
| Accessions |
EAW61710 EAW61711 EAW61712 Q9NW64 AK001152 BAA91521 AK096728 AK297019 BAG59551 AL136933 CAB66867 AM393639 CAL38515 BC003402 AAH03402 DA534416 N23415 NM_018047 NP_060517
|
| Function |
Involved in the first step of pre-mRNA splicing. Binds directly to the internal stem-loop (ISL) domain of the U6 snRNA and to the pre-mRNA intron near the 5' splice site during the activation and catalytic phases of the spliceosome cycle. Involved in both translocations of the nuclear SLU7 to the cytoplasm and the cytosolic calcium-binding protein PDCD6 to the nucleus upon cellular stress responses. {ECO:0000269|PubMed:17045351, ECO:0000269|PubMed:21122810, ECO:0000269|PubMed:22246180}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Mainly located in the nucleus. Translocated from the nucleus to the cytoplasm after heat shock cell treatment. May be shuttling between the nucleus and the cytosol.
|
| Top Pathways |
Spliceosome
|
![Western Blot: RBM22 Overexpression Lysate (Adult Normal) [NBL1-15200] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RBM22.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3862_RBM22%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15200-img0002.jpg)