TIMM8A

Gene Symbol TIMM8A
Entrez Gene 1678
Alt Symbol DDP, DDP1, DFN1, MTS, TIM8
Species Human
Gene Type protein-coding
Description translocase of inner mitochondrial membrane 8 homolog A (yeast)
Other Description X-linked deafness dystonia protein|deafness dystonia protein 1|deafness/dystonia peptide|mitochondrial import inner membrane translocase subunit Tim8 A
Swissprots Q6IRW6 B2R5A6 O60220
Accessions EAX02853 EAX02854 O60220 AK312117 BAG35053 AW204693 BC005236 BC006994 AAH06994 BC015093 AAH15093 BC070284 AAH70284 BM467820 BQ013177 CN410182 U66035 AAC15946 NM_001145951 NP_001139423 NM_004085 NP_004076 NM_032696
Function Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. Probably necessary for normal neurologic development. {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:15254020}.
Subcellular Location Mitochondrion inner membrane {ECO:0000269|PubMed:11489896}; Peripheral membrane protein {ECO:0000269|PubMed:11489896}; Intermembrane side {ECO:0000269|PubMed:11489896}.
Tissue Specificity Highly expressed in fetal and adult brain, followed by fetal lung, liver and kidney. Also expressed in heart, placenta, lung, liver, kidney, pancreas, skeletal muscle and heart.

Tim8A CRISPR/Cas9 KO Plasmid (h) - sc-410759 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Tim8A HDR Plasmid (h) - sc-410759-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Tim8A Double Nickase Plasmid (h) - sc-410759-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Tim8A Double Nickase Plasmid (h2) - sc-410759-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Tim8A CRISPR Activation Plasmid (h) - sc-410759-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Tim8A CRISPR Activation Plasmid (h2) - sc-410759-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Tim8A Lentiviral Activation Particles (h) - sc-410759-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Tim8A Lentiviral Activation Particles (h2) - sc-410759-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Tim8A siRNA (h) - sc-41247 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Tim8A shRNA Plasmid (h) - sc-41247-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Tim8A shRNA (h) Lentiviral Particles - sc-41247-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TIMM8A RNAi - H00001678-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU144971 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN21364 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21364 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06433 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr06433

TIMM8A siRNA (Human) - CRH1187 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TIMM8A - MBS8237062 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human TIMM8A (NM_004085.3) - SHH427472 from Creative biogene

Category siRNA
Species Reactivities Human

Human TIMM8A siRNA - orb261689 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TIMM8A shRNA Plasmid (Human) - CHH1187 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

TIMM8A miRNA 3'UTR clone - MiUTR4H-TG08981 from Creative biogene

Species Reactivities Human
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