Gene Symbol | TIMM8A |
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Entrez Gene | 1678 |
Alt Symbol | DDP, DDP1, DFN1, MTS, TIM8 |
Species | Human |
Gene Type | protein-coding |
Description | translocase of inner mitochondrial membrane 8 homolog A (yeast) |
Other Description | X-linked deafness dystonia protein|deafness dystonia protein 1|deafness/dystonia peptide|mitochondrial import inner membrane translocase subunit Tim8 A |
Swissprots | Q6IRW6 B2R5A6 O60220 |
Accessions | EAX02853 EAX02854 O60220 AK312117 BAG35053 AW204693 BC005236 BC006994 AAH06994 BC015093 AAH15093 BC070284 AAH70284 BM467820 BQ013177 CN410182 U66035 AAC15946 NM_001145951 NP_001139423 NM_004085 NP_004076 NM_032696 |
Function | Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIMM8-TIMM13 complex mediates the import of proteins such as TIMM23, SLC25A12/ARALAR1 and SLC25A13/ARALAR2, while the predominant TIMM9-TIMM10 70 kDa complex mediates the import of much more proteins. Probably necessary for normal neurologic development. {ECO:0000269|PubMed:11489896, ECO:0000269|PubMed:15254020}. |
Subcellular Location | Mitochondrion inner membrane {ECO:0000269|PubMed:11489896}; Peripheral membrane protein {ECO:0000269|PubMed:11489896}; Intermembrane side {ECO:0000269|PubMed:11489896}. |
Tissue Specificity | Highly expressed in fetal and adult brain, followed by fetal lung, liver and kidney. Also expressed in heart, placenta, lung, liver, kidney, pancreas, skeletal muscle and heart. |
Tim8A (N-20) - sc-17052 from Santa Cruz Biotechnology
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Tim8A (T-40) - sc-101282 from Santa Cruz Biotechnology
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Anti-TIMM8A antibody - ab168835 from Abcam
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Anti-TIMM8A antibody - ab88311 from Abcam
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Anti-TIMM8A antibody - ab54598 from Abcam
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Anti-TIMM8A Antibody (clone 2F11) - LS-C133151 from LifeSpan Bioscience
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Anti-TIMM8A Antibody (aa1-50) - LS-C290644 from LifeSpan Bioscience
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TIMM8A Antibody - NBP1-84288 from Novus Biologicals
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TIMM8A Antibody (2F11) - H00001678-M01 from Novus Biologicals
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TIMM8A Antibody - H00001678-B01 from Novus Biologicals
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TIMM8A Antibody - H00001678-B01P from Novus Biologicals
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TIMM8A Antibody - H00001678-A01 from Novus Biologicals
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TIMM8A Antibody (1A12) - H00001678-M04 from Novus Biologicals
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TIMM8A Polyclonal Antibody - bs-11769R from Bioss
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TIMM8A Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11769R-A350 from Bioss
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TIMM8A Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11769R-A488 from Bioss
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TIMM8A Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11769R-A555 from Bioss
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TIMM8A Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-11769R-A647 from Bioss
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TIMM8A Polyclonal Antibody, Cy3 Conjugated - bs-11769R-Cy3 from Bioss
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TIMM8A Polyclonal Antibody, Cy5 Conjugated - bs-11769R-Cy5 from Bioss
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TIMM8A Polyclonal Antibody, Cy5.5 Conjugated - bs-11769R-Cy5.5 from Bioss
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TIMM8A Polyclonal Antibody, Cy7 Conjugated - bs-11769R-Cy7 from Bioss
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TIMM8A Polyclonal Antibody, FITC Conjugated - bs-11769R-FITC from Bioss
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TIMM8A Polyclonal Antibody, Biotin Conjugated - bs-11769R-Biotin from Bioss
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TIMM8A Polyclonal Antibody, HRP Conjugated - bs-11769R-HRP from Bioss
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