| Gene Symbol |
SP100
|
| Entrez Gene |
6672
|
| Alt Symbol |
lysp100b
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SP100 nuclear antigen
|
| Other Description |
SP100-HMG nuclear autoantigen|nuclear autoantigen Sp-100|nuclear dot-associated Sp100 protein|speckled 100 kDa
|
| Swissprots |
Q13343 Q96T95 P23497 Q96F70 O75450 Q9UE32 F8WFE2 Q9NP33 Q96T24 B8ZZD8 E9PH61 B4DDX5 E7EUA7 Q8TE34
|
| Accessions |
AAF39781 AAF43098 AAK57703 AAX88870 AAY14879 CAA64744 EAW70927 EAW70928 EAW70929 P23497 AA810108 AF056322 AAC39790 AF255565 AAK51202 AI886092 AK090565 AK091898 AK126529 AK160379 BAD18722 AK293373 BAG56886 AK304205 BAG65081 AW978040 BC011562 AAH11562 CR749288 CAH18143 DA442074 DA562355 L79986 AAL77441 L79987 AAL77439 L79988 AAL77438 L79989 AAL77440 M60618 AAA35537 U36501 AAC50743 NM_001080391 NP_001073860 NM_001206701 NP_001193630 NM_001206702 NP_001193631 NM_001206703 NP_001193632 NM_001206704 NP_001193633 NM_003113 NP_003104
|
| Function |
Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53- mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation. {ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:14647468, ECO:0
|
| Subcellular Location |
Nucleus. Nucleus, PML body. Cytoplasm. Note=Differences in the subnuclear localization of the different isoforms seem to exist and may also be cell cycle- and interferon- dependent. Accumulates in the cytoplasm upon FAS activation.
|
| Tissue Specificity |
Widely expressed. Sp100-B is expressed only in spleen, tonsil, thymus, mature B-cell line and some T-cell line, but not in brain, liver, muscle or non-lymphoid cell lines.
|
| Top Pathways |
Herpes simplex infection, Viral carcinogenesis
|
