SP100

Gene Symbol	SP100
Entrez Gene	6672
Alt Symbol	lysp100b
Species	Human
Gene Type	protein-coding
Description	SP100 nuclear antigen
Other Description	SP100-HMG nuclear autoantigen|nuclear autoantigen Sp-100|nuclear dot-associated Sp100 protein|speckled 100 kDa
Swissprots	Q13343 Q96T95 P23497 Q96F70 O75450 Q9UE32 F8WFE2 Q9NP33 Q96T24 B8ZZD8 E9PH61 B4DDX5 E7EUA7 Q8TE34
Accessions	AAF39781 AAF43098 AAK57703 AAX88870 AAY14879 CAA64744 EAW70927 EAW70928 EAW70929 P23497 AA810108 AF056322 AAC39790 AF255565 AAK51202 AI886092 AK090565 AK091898 AK126529 AK160379 BAD18722 AK293373 BAG56886 AK304205 BAG65081 AW978040 BC011562 AAH11562 CR749288 CAH18143 DA442074 DA562355 L79986 AAL77441 L79987 AAL77439 L79988 AAL77438 L79989 AAL77440 M60618 AAA35537 U36501 AAC50743 NM_001080391 NP_001073860 NM_001206701 NP_001193630 NM_001206702 NP_001193631 NM_001206703 NP_001193632 NM_001206704 NP_001193633 NM_003113 NP_003104
Function	Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53- mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation. {ECO:0000269|PubMed:11909962, ECO:0000269|PubMed:14647468, ECO:0
Subcellular Location	Nucleus. Nucleus, PML body. Cytoplasm. Note=Differences in the subnuclear localization of the different isoforms seem to exist and may also be cell cycle- and interferon- dependent. Accumulates in the cytoplasm upon FAS activation.
Tissue Specificity	Widely expressed. Sp100-B is expressed only in spleen, tonsil, thymus, mature B-cell line and some T-cell line, but not in brain, liver, muscle or non-lymphoid cell lines.
Top Pathways	Herpes simplex infection, Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SP100 full length protein - ab114587 from Abcam Category Protein Source Wheat germ Species Human

Human SP100 peptide - ab44037 from Abcam Category Peptide

Human SP100 protein fragment - ab114588 from Abcam Category Protein Source Wheat germ Species Human

SP100 Antibody Blocking Peptide - LS-E3557 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SP100 Protein - H00006672-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SP100 Recombinant Protein - H00006672-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

SP100-Antibody-N-term-Blocking-Peptide - BP14754a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SP100 Protein (OPPA00172) - OPPA00172 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source Sf9 insect cells.

Human SP100 protein - orb169341 from Biorbyt Category Protein Prices $230.00, $442.00 Sizes 5 μg, 20 μg Source Sf9 insect cells. Species Human

SP100 protein (His tag) - 80-1387 from Fitzgerald Category Protein Prices $95.00, $495.00 Sizes 100 µg, 1 mg Source E.coli Species Human

SP100 - H00006672-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SP100 - H00006672-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SP100 - H00006672-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SP100 - H00006672-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SP100 Recombinant Human - 228-12864-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Human SP100 - 228-12864-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Sf9 insect cells. Species Human

Recombinant Human SP100 - 228-12864-3 from RayBiotech Category Protein Source Sf9 insect cells. Species Human

SP100 fusion protein - ag1939 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

SP100 Human - PRPS-115 from NeoScientific Category Protein Prices $65.00, $169.00, $5,070.00 Sizes 5 µg, 20 µg, 1 mg Source Sf9 insect cells. Species Human

Recombinant Human Speckled 100 kDa Protein - BP002252-PRO-108 from Syd Labs Category Protein Prices $160.00, $3,900.00 Sizes 20 µg, 1 mg Source Sf9 insect cells-derived. Species Human

SP100 Human Protein - GWB-BSP674 from Genway Biotech Category Protein Prices $75.00, $165.00, $4,375.00 Sizes 5 μg, 20 μg, 1000 μg Source Sf9 insect cells. Species Human

Recombinant Human SP100 - SP100-30988TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human SP100 - SP100-30989TH from Creative Biomart Category Protein Source Wheat germ

SP100 - NKX-504 from Reagent Proteins Category Protein Prices $280.00, $4,060.00 Sizes 20.00 µg, 1 mg Source Sf9 insect cells.

Recombinant Sp100 Nuclear Antigen (Sp100) - RPA326Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

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