SP100

Gene Symbol	SP100
Entrez Gene	6672
Alt Symbol	lysp100b
Species	Human
Gene Type	protein-coding
Description	SP100 nuclear antigen
Other Description	SP100-HMG nuclear autoantigen\|nuclear autoantigen Sp-100\|nuclear dot-associated Sp100 protein\|speckled 100 kDa
Swissprots	Q13343 Q96T95 P23497 Q96F70 O75450 Q9UE32 F8WFE2 Q9NP33 Q96T24 B8ZZD8 E9PH61 B4DDX5 E7EUA7 Q8TE34
Accessions	AAF39781 AAF43098 AAK57703 AAX88870 AAY14879 CAA64744 EAW70927 EAW70928 EAW70929 P23497 AA810108 AF056322 AAC39790 AF255565 AAK51202 AI886092 AK090565 AK091898 AK126529 AK160379 BAD18722 AK293373 BAG56886 AK304205 BAG65081 AW978040 BC011562 AAH11562 CR749288 CAH18143 DA442074 DA562355 L79986 AAL77441 L79987 AAL77439 L79988 AAL77438 L79989 AAL77440 M60618 AAA35537 U36501 AAC50743 NM_001080391 NP_001073860 NM_001206701 NP_001193630 NM_001206702 NP_001193631 NM_001206703 NP_001193632 NM_001206704 NP_001193633 NM_003113 NP_003104
Function	Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53- mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation. {ECO:0000269\|PubMed:11909962, ECO:0000269\|PubMed:14647468, ECO:0
Subcellular Location	Nucleus. Nucleus, PML body. Cytoplasm. Note=Differences in the subnuclear localization of the different isoforms seem to exist and may also be cell cycle- and interferon- dependent. Accumulates in the cytoplasm upon FAS activation.
Tissue Specificity	Widely expressed. Sp100-B is expressed only in spleen, tonsil, thymus, mature B-cell line and some T-cell line, but not in brain, liver, muscle or non-lymphoid cell lines.
Top Pathways	Herpes simplex infection, Viral carcinogenesis

SP-100 (N-20) - sc-16328 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

SP-100 (N-20): sc-16328. Western blot analysis of SP-100 expression in BJAB (A), HeLa (B) and C32 (C) nuclear extracts.

SP-100 (H-60) - sc-25568 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

SP-100 (H-60): sc-25568. Western blot analysis of SP-100 expression in c4 whole cell lysate.

Anti-SP100 antibody - ab43151 from Abcam

Prices	$388.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-SP100 antibody (ab43151) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell LysateLane 2 : Ramos (Human Burkitt's lymphoma cell line) Whole Cell LysateLane 3 : Hodgkin's Lymphoma (Human) Whole Cell Lysate - tumor tissue (ab29923)Lane 4 : Lymphoma (Human) Whole Cell Lysate - tumor tissue (ab30185)Lane 5 : MCF7 (Human breast adenocarcinoma cell line) Whole Cell LysateLane 6 : ZR-75-1 (Human breast carcinoma cell line) Nuclear lysate (ab14916)Lysates/proteins at 10 µg per lane.SecondaryIRDye 680 Conjugated Goat Anti-Rabbit IgG (H+L) at 1/10000 dilutionPerformed under reducing conditions.

Anti-SP100 antibody - ab167605 from Abcam

Prices	$378.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

All lanes : Anti-SP100 antibody (ab167605) at 1 µg/mlLane 1 : SP100 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.

Anti-SP100 antibody - ab58206 from Abcam

Prices	$378.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Western blot against tagged recombinant protein immunogen using ab58206 SP100 antibody at 1ug/ml.

Anti-SP100 antibody - ab192519 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SP100 antibody - C-terminal - ab187758 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SP100 Antibody (aa261-465) - LS-C296479 from LifeSpan Bioscience

Prices	$385.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SP100 Antibody (aa664-677) - LS-C313378 from LifeSpan Bioscience

Prices	$305.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

WB of SP100 antibody. All lanes: Anti-SP100 at 0.5ug/ml. Lane 1: U937 Whole Cell Lysate at 40ug. Lane 2: HEPG2 Whole Cell Lysate at 40ug. Predicted bind size: 100KD. Observed bind size: 100KD.

Anti-SP100 Antibody - LS-C334338 from LifeSpan Bioscience

Prices	$255.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts of various cell lines, using SP100 antibody.

Anti-SP100 Antibody (aa610-802) - LS-C314466 from LifeSpan Bioscience

Prices	$375.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SP100 Antibody (aa1-480) - LS-C132167 from LifeSpan Bioscience

Prices	$465.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SP100 Antibody (aa1-99) - LS-C132168 from LifeSpan Bioscience

Prices	$445.00
Sizes	100 µg
Host	Mouse
Clonality	Monoclonal

Anti-SP100 Antibody (aa199-227, AP) - LS-C270048 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SP100 Antibody (aa199-227, APC) - LS-C270050 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SP100 Antibody (aa199-227, Biotin) - LS-C270051 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SP100 Antibody (aa199-227, FITC) - LS-C270052 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SP100 Antibody (aa199-227, Azide-free, HRP) - LS-C270053 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SP100 Antibody (aa199-227, PE) - LS-C270054 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SP100 Antibody (aa261-465, Biotin) - LS-C299478 from LifeSpan Bioscience

Prices	$405.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SP100 Antibody (aa261-465, FITC) - LS-C302975 from LifeSpan Bioscience

Prices	$435.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SP100 Antibody (aa198-227) - LS-C325293 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-SP100 Antibody - LS-C341908 from LifeSpan Bioscience

Prices	$385.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-SP100 Antibody (aa199-227) - LS-C161408 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

SP100 Antibody western blot of ZR-75-1 cell line lysates (35 ug/lane). The SP100 antibody detected the SP100 protein (arrow).

Anti-SP100 Antibody (Internal) - LS-C345248 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of SP100 Antibody with human 721_B Whole Cell lysate.

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