| Gene Symbol | INMT |
|---|---|
| Entrez Gene | 11185 |
| Alt Symbol | TEMT |
| Species | Human |
| Gene Type | protein-coding |
| Description | indolethylamine N-methyltransferase |
| Other Description | amine N-methyltransferase|aromatic alkylamine N-methyltransferase|arylamine N-methyltransferase|indolamine N-methyltransferase|nicotine N-methyltransferase|thioether S-methyltransferase |
| Swissprots | B8ZZ69 Q9UBY4 Q9UHQ0 Q3KP49 Q9P1Y2 O95050 |
| Accessions | AAD04723 AAF18306 BAA94451 EAL24447 O95050 AF128846 AAF18304 AF128847 AAF18305 AK309519 AK313832 BC033813 AAH33813 BC103712 AAI03713 BC106902 AAI06903 BC106903 AAI06904 DA920005 NM_001199219 NP_001186148 NM_006774 NP_006765 |
| Function | Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2- methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds (By similarity). Catalyzes the N-methylation of tryptamine and structurally related compounds. {ECO:0000250, ECO:0000269|PubMed:10552930}. |
| Subcellular Location | Cytoplasm {ECO:0000250}. |
| Tissue Specificity | Widely expressed. The highest levels were in thyroid, adrenal gland, adult and fetal lung. Intermediate levels in heart, placenta, skeletal muscle, testis, small intestine, pancreas, stomach, spinal cord, lymph node and trachea. Very low levels in adult and fetal kidney and liver, in adult spleen, thymus, ovary, colon and bone marrow. Not expressed in peripheral blood leukocytes and brain. {ECO:0000269|PubMed:10552930}. |
| Top Pathways | Selenocompound metabolism, Tryptophan metabolism |