| Gene Symbol |
POU2F2
|
| Entrez Gene |
5452
|
| Alt Symbol |
OCT2, OTF2, Oct-2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
POU class 2 homeobox 2
|
| Other Description |
OTF-2|POU domain, class 2, transcription factor 2|homeobox protein|lymphoid-restricted immunoglobulin octamer-binding protein NF-A2|octamer-binding protein 2|octamer-binding transcription factor 2
|
| Swissprots |
Q9BRS4 Q16648 P09086 Q7M4M8
|
| Accessions |
CAA56933 EAW57098 EAW57099 EAW57100 EAW57101 EAW57102 EAW57103 EAW57104 EAW57105 EAW57106 EAW57107 P09086 AA832036 BC006101 AAH06101 BF062323 BT007438 AAP36106 CB995118 M22596 AAA64232 M36542 AAA36732 M36653 AAA36389 M36718 AAA59978 M36772 AAA36392 X13809 CAA32039 X13810 CAA32040 X53468 CAA37562 X53469 CAA37565 XM_005259010 XP_005259067 XM_011527040 XP_011525342 XM_011527041 XP_011525343 XM_011527042 XP_011525344 XM_011527043 XP_011525345 XM_011527044 XP_011525346 NM_001207025 NP_001193954 NM_001207026 NP_001193955 NM_001247994 NP_001234923 NM_002698 NP_002689
|
| Function |
Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter. {ECO:0000269|PubMed:1739980, ECO:0000269|PubMed:2328728, ECO:0000269|PubMed:2901913, ECO:0000269|PubMed:2904654}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus.
|
| Tissue Specificity |
Isoform 3 is B-cell specific. Isoform 5 is expressed in B-cells and the immunoglobulin-expressing T-cell line MOLT-4, but not in the T-cell line BW5147. {ECO:0000269|PubMed:2904654, ECO:0000269|PubMed:3072196}.
|