DCPS

Gene Symbol DCPS
Entrez Gene 28960
Alt Symbol DCS1, HINT-5, HINT5, HSL1, HSPC015
Species Human
Gene Type protein-coding
Description decapping enzyme, scavenger
Other Description decapping scavenger enzyme|heat shock-like protein 1|hint-related 7meGMP-directed hydrolase|histidine triad nucleotide-binding protein 5|histidine triad protein member 5|homolog of C. elegans 7meGMP-directed hydrolase dcs-1|m7GpppX diphosphatase|mRNA decapping enzyme|scavenger mRNA-decapping enzyme DcpS
Swissprots Q9Y2S5 Q96C86 Q8NHL8
Accessions EAW67691 Q96C86 AF077201 AAD26996 AF532613 AAM90310 AK026554 AK090828 AK223089 BAD96809 AK307403 AY040771 AAK91765 AY077684 AAL77216 BC014532 AAH14532 BE382749 HQ447210 ADQ31697 XM_011542778 XP_011541080 XM_011542779 XP_011541081 XM_011542780 XP_011541082 NM_014026 NP_054745
Function Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP (PubMed:22985415). May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCPS to m7GMP (PubMed:14523240). Binds t
Subcellular Location Cytoplasm. Nucleus. Note=Predominantly localized in the nucleus. Nucleocytoplasmic shuttling protein that can transiently enter the cytoplasm in mammalian cells in a XPO1/CRM1-dependent manner.
Tissue Specificity Detected in liver, brain, kidney, testis and prostate. {ECO:0000269|PubMed:12871939}.
Top Pathways RNA degradation

DCPS-Over-expression-Lysate - LY14115a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag DCPS (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the DCPS gene.

DCPS overexpression lysate - LY415527 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

DCPS 293 Cell Lysate - 407318 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

DCPS Overexpression Lysate (Native) - NBL1-09747 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: DCPS Overexpression Lysate (Adult Normal) [NBL1-09747] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DCPS.

DCPS Over-expression Lysate Product - GWB-12A88B from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

Panoply™ Human DCPS Knockdown Stable Cell Line - CSC-DC004093 from Creative biogene

Category Cell Line
Species Human
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