DCPS

Gene Symbol	DCPS
Entrez Gene	28960
Alt Symbol	DCS1, HINT-5, HINT5, HSL1, HSPC015
Species	Human
Gene Type	protein-coding
Description	decapping enzyme, scavenger
Other Description	decapping scavenger enzyme|heat shock-like protein 1|hint-related 7meGMP-directed hydrolase|histidine triad nucleotide-binding protein 5|histidine triad protein member 5|homolog of C. elegans 7meGMP-directed hydrolase dcs-1|m7GpppX diphosphatase|mRNA decapping enzyme|scavenger mRNA-decapping enzyme DcpS
Swissprots	Q9Y2S5 Q96C86 Q8NHL8
Accessions	EAW67691 Q96C86 AF077201 AAD26996 AF532613 AAM90310 AK026554 AK090828 AK223089 BAD96809 AK307403 AY040771 AAK91765 AY077684 AAL77216 BC014532 AAH14532 BE382749 HQ447210 ADQ31697 XM_011542778 XP_011541080 XM_011542779 XP_011541081 XM_011542780 XP_011541082 NM_014026 NP_054745
Function	Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP (PubMed:22985415). May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCPS to m7GMP (PubMed:14523240). Binds t
Subcellular Location	Cytoplasm. Nucleus. Note=Predominantly localized in the nucleus. Nucleocytoplasmic shuttling protein that can transiently enter the cytoplasm in mammalian cells in a XPO1/CRM1-dependent manner.
Tissue Specificity	Detected in liver, brain, kidney, testis and prostate. {ECO:0000269|PubMed:12871939}.
Top Pathways	RNA degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DCPS full length protein - ab113138 from Abcam Category Protein Source E. coli Species Human

DCPS Antibody Blocking Peptide - LS-E4729 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

DCPS Recombinant Protein - H00028960-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human DCPS Protein - NBP1-72406 from Novus Biologicals Category Protein Prices $349.00, $969.00 Sizes 50 µg, 250 µg Source E.coli Species Human

DCPS-Antibody-Center-Blocking-Peptide - BP17101c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human DCPS protein - orb168197 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

DCPS protein (His tag) - 80R-1923 from Fitzgerald Category Protein Prices $340.00 Sizes 50 µg Source E.coli

DCPS (1-337, His-tag) - AR39102PU-L from Acris Antibodies Category Protein Prices $1,020.00 Sizes 250 µg Source E. coli Species Human

DCPS (1-337, His-tag) - AR39102PU-N from Acris Antibodies Category Protein Prices $420.00 Sizes 50 µg Source E. coli Species Human

DCPS - H00028960-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

DCPS - H00028960-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Decapping Enzyme, Scavenger, Human Recombinant - 228-12310-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Species Human

Recombinant Human Decapping Enzyme, Scavenger - 228-12310-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Human Decapping Enzyme, Scavenger - 228-12310-3 from RayBiotech Category Protein Source Escherichia Coli. Species Human

DCPS, 1-337aa, Human, His tag, E.coli - 01-P1162 from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

DCPS fusion protein - Ag8872 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

DCPS fusion protein - Ag8726 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

DCPS Human - ENPS-166 from NeoScientific Category Protein Prices $65.00, $169.00, $6,760.00 Sizes 2 µg, 10 µg, 1 mg Source Escherichia Coli. Species Human

Recombinant Human Decapping Enzyme, Scavenger - BP002584-ENZ-159 from Syd Labs Category Protein Prices $160.00, $5,200.00 Sizes 10 µg, 1 mg Source E. coli-derived. Species Human

DCPS, 1-337aa, Recombinant Protein - GWB-P0876E from Genway Biotech Category Protein Prices $400.00, $1,200.00 Sizes 50 μg, 250 μg Source E.coli Species Human

Recombinant Human DCPS, His-tagged - DCPS-1011H from Creative Biomart Category Protein

Recombinant Human Decapping Enzyme, Scavenger, His-tagged - DCPS-1680H from Creative Biomart Category Protein Source Human

Recombinant Human DCPS, His-tagged - DCPS-27368TH from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human DCPS, His-tagged - DCPS-11862H from Creative Biomart Category Protein Source E.coli Species Human

DCPS 1-337aa - CMB-995 from Reagent Proteins Category Protein Prices $539.00, $1,099.00 Sizes 50.00 µg, 250.00 µg Source E.coli Species Human

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