DCPS
| Gene Symbol | DCPS |
|---|---|
| Entrez Gene | 28960 |
| Alt Symbol | DCS1, HINT-5, HINT5, HSL1, HSPC015 |
| Species | Human |
| Gene Type | protein-coding |
| Description | decapping enzyme, scavenger |
| Other Description | decapping scavenger enzyme|heat shock-like protein 1|hint-related 7meGMP-directed hydrolase|histidine triad nucleotide-binding protein 5|histidine triad protein member 5|homolog of C. elegans 7meGMP-directed hydrolase dcs-1|m7GpppX diphosphatase|mRNA decapping enzyme|scavenger mRNA-decapping enzyme DcpS |
| Swissprots | Q9Y2S5 Q96C86 Q8NHL8 |
| Accessions | EAW67691 Q96C86 AF077201 AAD26996 AF532613 AAM90310 AK026554 AK090828 AK223089 BAD96809 AK307403 AY040771 AAK91765 AY077684 AAL77216 BC014532 AAH14532 BE382749 HQ447210 ADQ31697 XM_011542778 XP_011541080 XM_011542779 XP_011541081 XM_011542780 XP_011541082 NM_014026 NP_054745 |
| Function | Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway. Hydrolyzes cap analog structures like 7-methylguanosine nucleoside triphosphate (m7GpppG) with up to 10 nucleotide substrates (small capped oligoribonucleotides) and specifically releases 5'-phosphorylated RNA fragments and 7-methylguanosine monophosphate (m7GMP). Cleaves cap analog structures like tri-methyl guanosine nucleoside triphosphate (m3(2,2,7)GpppG) with very poor efficiency. Does not hydrolyze unmethylated cap analog (GpppG) and shows no decapping activity on intact m7GpppG-capped mRNA molecules longer than 25 nucleotides. Does not hydrolyze 7-methylguanosine diphosphate (m7GDP) to m7GMP (PubMed:22985415). May also play a role in the 5'->3 mRNA decay pathway; m7GDP, the downstream product released by the 5'->3' mRNA mediated decapping activity, may be also converted by DCPS to m7GMP (PubMed:14523240). Binds t |
| Subcellular Location | Cytoplasm. Nucleus. Note=Predominantly localized in the nucleus. Nucleocytoplasmic shuttling protein that can transiently enter the cytoplasm in mammalian cells in a XPO1/CRM1-dependent manner. |
| Tissue Specificity | Detected in liver, brain, kidney, testis and prostate. {ECO:0000269|PubMed:12871939}. |
| Top Pathways | RNA degradation |
DcpS CRISPR/Cas9 KO Plasmid (h) - sc-407308 from Santa Cruz Biotechnology
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DcpS HDR Plasmid (h) - sc-407308-HDR from Santa Cruz Biotechnology
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DcpS Double Nickase Plasmid (h) - sc-407308-NIC from Santa Cruz Biotechnology
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DcpS Double Nickase Plasmid (h2) - sc-407308-NIC-2 from Santa Cruz Biotechnology
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DcpS CRISPR Activation Plasmid (h) - sc-407308-ACT from Santa Cruz Biotechnology
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DcpS CRISPR Activation Plasmid (h2) - sc-407308-ACT-2 from Santa Cruz Biotechnology
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DcpS Lentiviral Activation Particles (h) - sc-407308-LAC from Santa Cruz Biotechnology
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DcpS Lentiviral Activation Particles (h2) - sc-407308-LAC-2 from Santa Cruz Biotechnology
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DcpS siRNA (h) - sc-44389 from Santa Cruz Biotechnology
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DcpS shRNA Plasmid (h) - sc-44389-SH from Santa Cruz Biotechnology
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DcpS shRNA (h) Lentiviral Particles - sc-44389-V from Santa Cruz Biotechnology
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DCPS RNAi - H00028960-R01 from Novus Biologicals
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MISSION® esiRNA - EHU037381 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6998 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6998 from Sigma-Aldrich
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DCPS siRNA (Human) - CRH9129 from Cohesion Biosciences
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DCPS - MBS8213028 from MyBioSource
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DcpS CRISPR/Cas9 KO Plasmid (h2) - sc-407308-KO-2 from Santa Cruz Biotechnology
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DcpS HDR Plasmid (h2) - sc-407308-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human DCPS (NM_014026.3) - SHH275301 from Creative biogene
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shRNA set against Human DCPS(NM_014026.3) - SHG224363 from Creative biogene
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DCPS shRNA Plasmid (Human) - CHH9129 from Cohesion Biosciences
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DCPS miRNA 3'UTR clone - MiUTR1H-02695 from Creative biogene
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