| Gene Symbol |
ERCC3
|
| Entrez Gene |
2071
|
| Alt Symbol |
BTF2, GTF2H, RAD25, TFIIH, XPB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
excision repair cross-complementation group 3
|
| Other Description |
BTF2 p89|DNA excision repair protein ERCC-3|DNA repair helicase|DNA repair protein complementing XP-B cells|TFIIH 89 kDa subunit|TFIIH basal transcription factor complex 89 kDa subunit|TFIIH basal transcription factor complex helicase XPB subunit|TFIIH p89|basic transcription factor 2 89 kDa subunit|excision repair cross-complementing rodent repair deficiency, complementation group 3|xeroderma pigmentosum group B-complementing protein|xeroderma pigmentosum, complementation group B
|
| Swissprots |
Q53QM0 P19447
|
| Accessions |
AAN46739 AAY15069 EAW95311 EAW95312 EAW95313 EAW95314 P19447 AI222871 AK091500 BAG52374 AK095557 BAG53083 AK126697 AK127469 AK222465 BAD96185 AK290474 BAF83163 AK300250 BAG62016 AK307338 AK309405 BC008820 AAH08820 DQ893802 ABM84728 EU176179 ABW03630 M31899 AAA52396 XM_011510794 XP_011509096 XM_011510795 XP_011509097 NM_000122 NP_000113 NM_001303416 NP_001290345 NM_001303418 NP_001290347
|
| Function |
ATP-dependent 3'-5' DNA helicase, component of the core- TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Acts by opening DNA either around the RNA transcription start site or the DNA damage. {ECO:0000269|PubMed:10024882, ECO:0000269|PubMed:8157004}.
|
| Subcellular Location |
Nucleus.
|
| Top Pathways |
Nucleotide excision repair, Basal transcription factors
|