| Gene Symbol | AR |
|---|---|
| Entrez Gene | 367 |
| Alt Symbol | AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM |
| Species | Human |
| Gene Type | protein-coding |
| Description | androgen receptor |
| Other Description | androgen nuclear receptor variant 2|dihydrotestosterone receptor|nuclear receptor subfamily 3 group C member 4 |
| Swissprots | A2RUN2 Q9UD95 P10275 B1AKD7 |
| Accessions | AAA51772 AAA51778 AAA51886 AAB21256 AAB21257 AAB60346 AAF04001 CAA55328 CCV20035 EAX05380 P10275 AF162704 AAD45921 AF321914 AAK09423 AF321915 AAK09424 AF321916 AAK09425 AF321917 AAK09426 AI352339 BC132975 AAI32976 FJ235916 ACN39559 FJ235917 ACN39560 FJ235918 ACN39561 FJ235919 ACN39562 FJ235920 ACN39563 GU208210 ACZ81436 HM055487 ADK91081 HQ692823 ADZ17334 KF720403 AHC70786 KF720404 AHC70787 KF720405 AHC70788 KJ534771 AHW56411 L29496 AAA51770 M20132 AAA51729 M20260 AAA51774 M21748 AAA51771 M23263 AAA51775 M34233 AAA51780 M73069 AAA51735 NM_000044 NP_000035 NM_001011645 NP_001011645 |
| Function | Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. {ECO:0000269|PubMed:14664718, ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:17911242, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:20980437}. |
| Subcellular Location | Nucleus. Cytoplasm. Note=Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of GNB2L1. |
| Tissue Specificity | Isoform 2 is mainly expressed in heart and skeletal muscle. {ECO:0000269|PubMed:15634333}. |
| Top Pathways | Prostate cancer, Oocyte meiosis |