AR

Gene Symbol AR
Entrez Gene 367
Alt Symbol AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM
Species Human
Gene Type protein-coding
Description androgen receptor
Other Description androgen nuclear receptor variant 2|dihydrotestosterone receptor|nuclear receptor subfamily 3 group C member 4
Swissprots A2RUN2 Q9UD95 P10275 B1AKD7
Accessions AAA51772 AAA51778 AAA51886 AAB21256 AAB21257 AAB60346 AAF04001 CAA55328 CCV20035 EAX05380 P10275 AF162704 AAD45921 AF321914 AAK09423 AF321915 AAK09424 AF321916 AAK09425 AF321917 AAK09426 AI352339 BC132975 AAI32976 FJ235916 ACN39559 FJ235917 ACN39560 FJ235918 ACN39561 FJ235919 ACN39562 FJ235920 ACN39563 GU208210 ACZ81436 HM055487 ADK91081 HQ692823 ADZ17334 KF720403 AHC70786 KF720404 AHC70787 KF720405 AHC70788 KJ534771 AHW56411 L29496 AAA51770 M20132 AAA51729 M20260 AAA51774 M21748 AAA51771 M23263 AAA51775 M34233 AAA51780 M73069 AAA51735 NM_000044 NP_000035 NM_001011645 NP_001011645
Function Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. {ECO:0000269|PubMed:14664718, ECO:0000269|PubMed:15563469, ECO:0000269|PubMed:17591767, ECO:0000269|PubMed:17911242, ECO:0000269|PubMed:18084323, ECO:0000269|PubMed:19345326, ECO:0000269|PubMed:20980437}.
Subcellular Location Nucleus. Cytoplasm. Note=Predominantly cytoplasmic in unligated form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unligated form in the presence of GNB2L1.
Tissue Specificity Isoform 2 is mainly expressed in heart and skeletal muscle. {ECO:0000269|PubMed:15634333}.
Top Pathways Prostate cancer, Oocyte meiosis

AR CRISPR/Cas9 KO Plasmid (h) - sc-400026 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AR HDR Plasmid (h) - sc-400026-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AR Double Nickase Plasmid (h) - sc-400026-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AR Double Nickase Plasmid (h2) - sc-400026-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AR CRISPR Activation Plasmid (h) - sc-400026-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AR CRISPR Activation Plasmid (h2) - sc-400026-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

AR Lentiviral Activation Particles (h) - sc-400026-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AR Lentiviral Activation Particles (h2) - sc-400026-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

AR siRNA (h) - sc-29204 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

AR shRNA Plasmid (h) - sc-29204-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

AR shRNA (h) Lentiviral Particles - sc-29204-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU101051 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® esiRNA - EHU025951 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1004 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1004 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

AR siRNA (Human) - CRH0262 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Androgen R/NR3C4 RNAi - H00000367-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

AR - MBS828823 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

AR shRNA Plasmid (Human) - CHH0262 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

AR miRNA 3'UTR clone - MiUTR3H-03025 from Creative biogene

Species Reactivities Human

AR miRNA 3'UTR clone - MiUTR3H-03026 from Creative biogene

Species Reactivities Human
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