Gene Symbol | METAP1 |
---|---|
Entrez Gene | 23173 |
Alt Symbol | MAP1A, MetAP1A |
Species | Human |
Gene Type | protein-coding |
Description | methionyl aminopeptidase 1 |
Other Description | MAP 1|metAP 1|methionine aminopeptidase 1|peptidase M 1 |
Swissprots | B4E2E6 P53582 |
Accessions | EAX06082 EAX06083 P53582 AK304239 BAG65108 AK309465 BC030054 AAH30054 CR936632 CAI56775 D42084 BAA07679 DA178462 XM_005262868 XP_005262925 XM_011531777 XP_011530079 XM_011531778 XP_011530080 XM_011531779 XP_011530081 NM_015143 NP_055958 |
Function | Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle. {ECO:0000255|HAMAP- Rule:MF_03174, ECO:0000269|PubMed:16274222, ECO:0000269|PubMed:17114291}. |
Subcellular Location | Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03174}. |