| Gene Symbol |
HDAC6
|
| Entrez Gene |
10013
|
| Alt Symbol |
CPBHM, HD6, JM21, PPP1R90
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
histone deacetylase 6
|
| Other Description |
protein phosphatase 1, regulatory subunit 90
|
| Swissprots |
Q96CY0 Q6NT75 O94975 Q9UBN7 Q7L3E5
|
| Accessions |
CAF04396 EAW50744 EAW50745 EAW50746 EAW50747 EAW50748 Q9UBN7 AB020708 BAA74924 AF132609 AAD29048 AF174499 AAF36540 AJ011972 CAA09893 AK001543 BAG50935 AK024083 BAG51263 AK095124 BAG52988 AK122954 BAG53817 AK127118 AK131286 BAG54760 AK295884 BAG58680 AK302926 BAG64088 AK303012 BAG64143 AK309058 AL137696 CAB70878 BC005872 AAH05872 BC011498 AAH11498 BC013219 BC013737 AAH13737 BC069243 AAH69243 BT006649 AAP35295 JF432329 ADZ15546 XM_005272564 XP_005272621 XM_005272565 XP_005272622 XM_005272566 XP_005272623 XM_005272568 XP_005272625 XM_006724525 XP_006724588 XR_246712 XR_949014 NM_006044 NP_006035
|
| Function |
Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Plays a central role in microtubule-dependent cell motility via deacetylation of tubulin. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. {ECO:0000250}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Perikaryon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, axon {ECO:0000250}. Note=It is mainly cytoplasmic, where it is associated with microtubules.
|
| Top Pathways |
Viral carcinogenesis, Alcoholism
|