BCL2

Gene Symbol	BCL2
Entrez Gene	596
Alt Symbol	Bcl-2, PPP1R50
Species	Human
Gene Type	protein-coding
Description	B-cell CLL/lymphoma 2
Other Description	apoptosis regulator Bcl-2|protein phosphatase 1, regulatory subunit 50
Swissprots	Q13842 Q16197 C9JHD5 P10416 P10415
Accessions	AAD14111 AAO26045 CAR95111 CAR95112 CCA94580 CDM22285 CDM22286 EAW63136 EAW63137 EAW63138 EAW63139 P10415 AF401211 AAL02169 AI401297 BC027258 AAH27258 DQ891470 ABM82396 DQ894654 ABM85580 EU287875 ABX60202 M13994 AAA51813 M13995 AAA51814 M14745 AAA35591 X06487 CAA29778 XM_011526135 XP_011524437 XR_935246 XR_935247 XR_935248 NM_000633 NP_000624 NM_000657 NP_000648
Function	Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). {ECO:0000269|PubMed:18570871}.
Subcellular Location	Mitochondrion outer membrane {ECO:0000269|PubMed:2250705}; Single-pass membrane protein {ECO:0000269|PubMed:2250705}. Nucleus membrane {ECO:0000269|PubMed:2250705}; Single-pass membrane protein {ECO:0000269|PubMed:2250705}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:2250705}; Single-pass membrane protein {ECO:0000269|PubMed:2250705}.
Tissue Specificity	Expressed in a variety of tissues.
Top Pathways	Toxoplasmosis, Epstein-Barr virus infection, MicroRNAs in cancer, Adrenergic signaling in cardiomyocytes, Sphingolipid signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PathScan ® Phospho-Bcl-2 (Ser70) Sandwich ELISA Kit - 11874 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

PathScan ® Total Bcl-2 Sandwich ELISA Kit - 12030 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

SimpleChIP ® Human Bcl-2 Promoter Primers - 12924 from Cell Signaling Technology Category ChIP Kit Prices $102.00 Sizes 500 µl (250 PCR reactions)

Bcl-2 Human ELISA Kit - ab119506 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity 0.5 ng/ml Range 0.5 ng/ml - 32 ng/ml

Bcl-2 Human SimpleStep ELISA® Kit - ab202411 from Abcam Category ELISA Kit Prices $470.00 Sizes 1 x 96 tests Sensitivity 1.4 ng/ml Range 3.125 ng/ml - 200 ng/ml

Mouse BCL2 / Bcl-2 ELISA Kit (Sandwich ELISA) - LS-F4136 from LifeSpan Bioscience Category ELISA Kit Prices $670.00 Sizes 1 plate Sensitivity 78.13 pg/ml Range 1.56-100 ng/ml

Rat BCL2 / Bcl-2 ELISA Kit (Sandwich ELISA) - LS-F4135 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 78.13 pg/ml Range 1.56-100 ng/ml

Human BCL2 / Bcl-2 ELISA Kit (Sandwich ELISA) - LS-F4134 from LifeSpan Bioscience Category ELISA Kit Prices $650.00 Sizes 1 plate Sensitivity 1.56 ng/ml Range 1.56-100 ng/ml

Mouse/Human/Rat BCL2 / Bcl-2 ELISA Kit (Cell-Based ELISA) - LS-F1822 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 1.56-100 ng/ml

Mouse/Rat Phospho-BCL2 / Bcl-2 (Ser87) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1156 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 1.56-100 ng/ml

Human Phospho-BCL2 / Bcl-2 (Ser70) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1462 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 1.56-100 ng/ml

Human Phospho-BCL2 / Bcl-2 (Thr56) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1463 from LifeSpan Bioscience Category ELISA Kit Prices $550.00 Sizes 1 plate Range 1.56-100 ng/ml

Bovine BCL2 / Bcl-2 ELISA Kit (Sandwich ELISA) - LS-F8816 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.55 ng/ml Range 1.56-100 ng/ml

Rat BCL2 / Bcl-2 ELISA Kit (Sandwich ELISA) - LS-F10920 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 1.56 Range 1.56-100 ng/ml

Human BCL2 / Bcl-2 ELISA Kit (Sandwich ELISA) - LS-F10922 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 78 Range 1.56-100 ng/ml

Bovine BCL2 / Bcl-2 ELISA Kit (Sandwich ELISA) - LS-F10921 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 1.56 Range 1.56-100 ng/ml

Mouse BCL2 / Bcl-2 ELISA Kit (Sandwich ELISA) - LS-F10923 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 1.56-100 ng/ml

Bcl2/Adenovirus E1B 19kD Interacting Protein 3 (BNIP3) BioAssay™ ECL Kit (Rat) - 157420 from USBiological Life Science Sensitivity The minimum detectable dose of this kit is typically less than 0.214ng/ml. Range 0.625-40ng/ml

Human Total Bcl-2 DuoSet IC ELISA - DYC827B-2 from R&D Systems Category ELISA Kit Prices $329.00, $649.00 Sizes 1 kit (for 2 Plates), 1 kit (for 5 Plates) Range 62.50 - 4,000 pg/mL

Human Total Bcl-2 DuoSet IC, 5 Plate - DYC827B-5 from R&D Systems Category ELISA Kit

Bcl2 ELISA kit - 55R-IB49641 from Fitzgerald Category ELISA Kit Prices $765.00 Sizes 96 wells

Bcl2 ELISA kit - 55R-IB09621 from Fitzgerald Category ELISA Kit Prices $805.00 Sizes 96 wells

Human Bcl2 ELISA Kit - abx150795 from Abbexa Category ELISA Kit Sensitivity 0.63 ng/ml Range 1.563 ng/ml - 100 ng/ml

Apoptosis regulator Bcl-2, BCL2, Human, ELISA Kit - E0778h from ARP American Research Products Category ELISA Kit Prices $576.00 Sizes 96 t Range 78-5000 pg/mL

B-Cell Leukemia/Lymphoma 2 (Bcl2), Human, ELISA Kit - SEA778Hu from ARP American Research Products Category ELISA Kit Prices $650.00 Sizes 96 t Sensitivity 0.57ng/mL Range 1.56-100ng/mL

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