BCL2

Gene Symbol	BCL2
Entrez Gene	596
Alt Symbol	Bcl-2, PPP1R50
Species	Human
Gene Type	protein-coding
Description	B-cell CLL/lymphoma 2
Other Description	apoptosis regulator Bcl-2|protein phosphatase 1, regulatory subunit 50
Swissprots	Q13842 Q16197 C9JHD5 P10416 P10415
Accessions	AAD14111 AAO26045 CAR95111 CAR95112 CCA94580 CDM22285 CDM22286 EAW63136 EAW63137 EAW63138 EAW63139 P10415 AF401211 AAL02169 AI401297 BC027258 AAH27258 DQ891470 ABM82396 DQ894654 ABM85580 EU287875 ABX60202 M13994 AAA51813 M13995 AAA51814 M14745 AAA35591 X06487 CAA29778 XM_011526135 XP_011524437 XR_935246 XR_935247 XR_935248 NM_000633 NP_000624 NM_000657 NP_000648
Function	Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). {ECO:0000269|PubMed:18570871}.
Subcellular Location	Mitochondrion outer membrane {ECO:0000269|PubMed:2250705}; Single-pass membrane protein {ECO:0000269|PubMed:2250705}. Nucleus membrane {ECO:0000269|PubMed:2250705}; Single-pass membrane protein {ECO:0000269|PubMed:2250705}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:2250705}; Single-pass membrane protein {ECO:0000269|PubMed:2250705}.
Tissue Specificity	Expressed in a variety of tissues.
Top Pathways	Toxoplasmosis, Epstein-Barr virus infection, MicroRNAs in cancer, Adrenergic signaling in cardiomyocytes, Sphingolipid signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Bcl-2 peptide - ab45606 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human Bcl-2 full length protein - ab85156 from Abcam Category Protein Prices $235.00 Sizes 20 µg Source E. coli Species Human

Human Bcl-2 peptide - ab7983 from Abcam Category Peptide Prices $181.00 Sizes 100 µg Species Human

Human Bcl-2 peptide - ab18624 from Abcam Category Peptide Prices $181.00 Sizes 100 µg Species Human

Human Bcl-2 protein fragment - ab84209 from Abcam Category Protein Prices $188.00 Sizes 50 µg Source E. coli Species Human

Human Bcl-2 protein fragment - ab59853 from Abcam Category Protein Prices $235.00 Sizes 5 µg Source E. coli Species Human

Human Bcl-2 protein fragment - ab79942 from Abcam Category Protein Source E. coli Species Human

Human Bcl-2 protein fragment - ab73696 from Abcam Category Protein Prices $188.00 Sizes 10 µg Source E. coli Species Human

BCL2 / Bcl-2 Antibody Blocking Peptide - LS-E2135 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BCL2 / Bcl-2 Antibody Blocking Peptide - LS-E2736 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BCL2 / Bcl-2 Antibody Blocking Peptide - LS-E10563 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BCL2 / Bcl-2 Antibody Blocking Peptide - LS-E25753 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BCL2 / Bcl-2 Antibody Blocking Peptide - LS-E6713 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BCL2 / Bcl-2 Antibody Blocking Peptide - LS-E21543 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BCL2 / Bcl-2 Antibody Blocking Peptide - LS-E30073 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

BCL2 / Bcl-2 Antibody Blocking Peptide - LS-E30074 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human Bcl-2 Protein - NBP2-34889 from Novus Biologicals Category Protein Prices $69.00, $169.00, $1,469.00 Sizes 5 µg, 20 µg, 1 mg Source E. coli Species Human

Bcl-2 Blocking Peptide - NB110-60984PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg Species Human

Bcl-2 Blocking Peptide - NB110-60982PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg Species Human

Bcl-2 Partial Recombinant Protein - H00000596-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Bcl-2 Recombinant Protein - H00000596-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg

BCL2-Antibody-N-term-Blocking-Peptide - BP19614a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Bcl-2-Antibody-BH3-Domain-Specific-Blocking-peptide - BP1303a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

BCL2-Antibody-Center-Blocking-peptide - BP13823c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

bcl-2-Antibody-Center-S70-Blocking-Peptide - BP19252c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

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