| Gene Symbol | BCL2 |
|---|---|
| Entrez Gene | 596 |
| Alt Symbol | Bcl-2, PPP1R50 |
| Species | Human |
| Gene Type | protein-coding |
| Description | B-cell CLL/lymphoma 2 |
| Other Description | apoptosis regulator Bcl-2|protein phosphatase 1, regulatory subunit 50 |
| Swissprots | Q13842 Q16197 C9JHD5 P10416 P10415 |
| Accessions | AAD14111 AAO26045 CAR95111 CAR95112 CCA94580 CDM22285 CDM22286 EAW63136 EAW63137 EAW63138 EAW63139 P10415 AF401211 AAL02169 AI401297 BC027258 AAH27258 DQ891470 ABM82396 DQ894654 ABM85580 EU287875 ABX60202 M13994 AAA51813 M13995 AAA51814 M14745 AAA35591 X06487 CAA29778 XM_011526135 XP_011524437 XR_935246 XR_935247 XR_935248 NM_000633 NP_000624 NM_000657 NP_000648 |
| Function | Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). {ECO:0000269|PubMed:18570871}. |
| Subcellular Location | Mitochondrion outer membrane {ECO:0000269|PubMed:2250705}; Single-pass membrane protein {ECO:0000269|PubMed:2250705}. Nucleus membrane {ECO:0000269|PubMed:2250705}; Single-pass membrane protein {ECO:0000269|PubMed:2250705}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:2250705}; Single-pass membrane protein {ECO:0000269|PubMed:2250705}. |
| Tissue Specificity | Expressed in a variety of tissues. |
| Top Pathways | Toxoplasmosis, Epstein-Barr virus infection, MicroRNAs in cancer, Adrenergic signaling in cardiomyocytes, Sphingolipid signaling pathway |