Gene Symbol | TRIM23 |
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Entrez Gene | 373 |
Alt Symbol | ARD1, ARFD1, RNF46 |
Species | Human |
Gene Type | protein-coding |
Description | tripartite motif containing 23 |
Other Description | ADP-ribosylation factor domain protein 1, 64kDa|ADP-ribosylation factor domain-containing protein 1|ARF domain protein 1|E3 ubiquitin-protein ligase TRIM23|GTP-binding protein ARD-1|RING finger protein 46|tripartite motif protein TRIM23|tripartite motif-containing 23|tripartite motif-containing protein 23 |
Swissprots | P36406 Q9BZY4 Q9BZY5 |
Accessions | EAW51349 EAW51350 EAW51351 P36406 AF230397 AAG50176 AF230398 AAG50177 AF230399 AAG50178 AI679928 AK292814 BAF85503 BC022510 AAH22510 BI859501 DQ893646 ABM84572 DQ895584 ABM86510 L04510 AAA35940 XM_005248497 XP_005248554 NM_001656 NP_001647 NM_033227 NP_150230 NM_033228 NP_150231 |
Function | Acts as an E3 ubiquitin-protein ligase. In the presence of the human cytomegalovirus (HCMV) protein UL144, participates in 'Lys-63'-linked auto-ubiquitination of TRAF6 resulting in the virally controlled activation of NF-kappa-B at early time of infection. The C-terminus can act as an allosteric activator of the cholera toxin catalytic subunit. {ECO:0000269|PubMed:15684077}. |
Subcellular Location | Endomembrane system {ECO:0000269|PubMed:9671726}. Golgi apparatus membrane {ECO:0000269|PubMed:9671726}. Lysosome membrane {ECO:0000269|PubMed:9671726}. Note=Membrane-associated with the Golgi complex and lysosomal structures. |
TRIM23 CRISPR/Cas9 KO Plasmid (h) - sc-407633 from Santa Cruz Biotechnology
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TRIM23 HDR Plasmid (h) - sc-407633-HDR from Santa Cruz Biotechnology
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TRIM23 Double Nickase Plasmid (h) - sc-407633-NIC from Santa Cruz Biotechnology
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TRIM23 Double Nickase Plasmid (h2) - sc-407633-NIC-2 from Santa Cruz Biotechnology
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TRIM23 CRISPR Activation Plasmid (h) - sc-407633-ACT from Santa Cruz Biotechnology
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TRIM23 CRISPR Activation Plasmid (h2) - sc-407633-ACT-2 from Santa Cruz Biotechnology
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TRIM23 Lentiviral Activation Particles (h) - sc-407633-LAC from Santa Cruz Biotechnology
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TRIM23 Lentiviral Activation Particles (h2) - sc-407633-LAC-2 from Santa Cruz Biotechnology
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TRIM23 siRNA (h) - sc-106640 from Santa Cruz Biotechnology
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TRIM23 shRNA Plasmid (h) - sc-106640-SH from Santa Cruz Biotechnology
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TRIM23 shRNA (h) Lentiviral Particles - sc-106640-V from Santa Cruz Biotechnology
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TRIM23 RNAi - H00000373-R06 from Novus Biologicals
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TRIM23 RNAi - H00000373-R05 from Novus Biologicals
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TRIM23 RNAi - H00000373-R04 from Novus Biologicals
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MISSION® esiRNA - EHU065131 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21962 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21962 from Sigma-Aldrich
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TRIM23 siRNA (Human) - CRH0266 from Cohesion Biosciences
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TRIM23 - MBS8212758 from MyBioSource
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shRNA set against Human TRIM23 (NM_001656.3) - SHH434484 from Creative biogene
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shRNA set against Human TRIM23(NM_001656.3) - SHG068137 from Creative biogene
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shRNA set against Human TRIM23(NM_033228.2) - SHG068165 from Creative biogene
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shRNA set against Human TRIM23(NM_033227.2) - SHG068183 from Creative biogene
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Human TRIM23 siRNA - orb260768 from Biorbyt
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TRIM23 shRNA Plasmid (Human) - CHH0266 from Cohesion Biosciences
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