Gene Symbol | CLK1 |
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Entrez Gene | 1195 |
Alt Symbol | CLK, CLK/STY, STY |
Species | Human |
Gene Type | protein-coding |
Description | CDC-like kinase 1 |
Other Description | CDC28/CDC2-like kinase|dual specificity protein kinase CLK1|protein tyrosine kinase STY |
Swissprots | Q0P694 Q8N5V8 B4DFW7 P49759 |
Accessions | AAY14722 CAV30732 EAW70215 EAW70216 EAW70217 EAW70218 EAW70219 P49759 AI251890 AK025306 AK289365 BAF82054 AK294295 BAG57578 AK307301 AK316127 BAH14498 BC028149 AAH28149 BC028573 BC031549 AAH31549 BE241788 DA225472 DB164846 L29219 AAA61480 L29222 AAB59459 M59287 NM_001162407 NP_001155879 NM_004071 NP_004062 NR_027855 NR_027856 NM_001024646 |
Function | Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA. {ECO:0000269|PubMed:10480872, ECO:0000269|PubMed:19168442}. |
Subcellular Location | Nucleus. |
Tissue Specificity | Endothelial cells. {ECO:0000269|PubMed:19168442}. |
Top Pathways | Legionellosis |
CLK1 (K-13) - sc-47957 from Santa Cruz Biotechnology
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CLK1 (N-17) - sc-47959 from Santa Cruz Biotechnology
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CLK1 (C-14) - sc-47956 from Santa Cruz Biotechnology
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CLK1/4 (K-19) - sc-47958 from Santa Cruz Biotechnology
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Anti-CLK1 antibody - ab74044 from Abcam
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Anti-CLK1 antibody - ab66994 from Abcam
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Anti-CLK1 antibody - ab151429 from Abcam
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Anti-CLK1 antibody - N-terminal - ab71408 from Abcam
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Anti-CLK1 / CLK Antibody (aa52-80, AP) - LS-C255035 from LifeSpan Bioscience
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Anti-CLK1 / CLK Antibody (aa52-80, Biotin) - LS-C255037 from LifeSpan Bioscience
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Anti-CLK1 / CLK Antibody (aa52-80, APC) - LS-C255036 from LifeSpan Bioscience
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Anti-CLK1 / CLK Antibody (aa52-80, FITC) - LS-C255038 from LifeSpan Bioscience
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Anti-CLK1 / CLK Antibody (aa52-80, Azide-free, HRP) - LS-C255039 from LifeSpan Bioscience
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Anti-CLK1 / CLK Antibody (aa52-80, PE) - LS-C255040 from LifeSpan Bioscience
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Anti-CLK1 / CLK Antibody (N-Terminus, AP) - LS-C276342 from LifeSpan Bioscience
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Anti-CLK1 / CLK Antibody (aa35-84) - LS-C135263 from LifeSpan Bioscience
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Anti-CLK1 / CLK Antibody (N-Terminus, FITC) - LS-C276345 from LifeSpan Bioscience
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Anti-CLK1 / CLK Antibody (N-Terminus, Biotin) - LS-C276344 from LifeSpan Bioscience
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Anti-CLK1 / CLK Antibody (N-Terminus, APC) - LS-C276343 from LifeSpan Bioscience
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Anti-CLK1 / CLK Antibody (N-Terminus, Azide-free, HRP) - LS-C276346 from LifeSpan Bioscience
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Anti-CLK1 / CLK Antibody - LS-C306994 from LifeSpan Bioscience
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Anti-CLK1 / CLK Antibody (aa52-80) - LS-C320446 from LifeSpan Bioscience
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Anti-CLK1 / CLK Antibody (N-Terminus, PE) - LS-C276347 from LifeSpan Bioscience
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Anti-CLK1 / CLK Antibody (N-Terminus) - LS-C99886 from LifeSpan Bioscience
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Anti-CLK1 / CLK Antibody (N-Terminus) - LS-C330380 from LifeSpan Bioscience
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