CLK1

Gene Symbol	CLK1
Entrez Gene	1195
Alt Symbol	CLK, CLK/STY, STY
Species	Human
Gene Type	protein-coding
Description	CDC-like kinase 1
Other Description	CDC28/CDC2-like kinase|dual specificity protein kinase CLK1|protein tyrosine kinase STY
Swissprots	Q0P694 Q8N5V8 B4DFW7 P49759
Accessions	AAY14722 CAV30732 EAW70215 EAW70216 EAW70217 EAW70218 EAW70219 P49759 AI251890 AK025306 AK289365 BAF82054 AK294295 BAG57578 AK307301 AK316127 BAH14498 BC028149 AAH28149 BC028573 BC031549 AAH31549 BE241788 DA225472 DB164846 L29219 AAA61480 L29222 AAB59459 M59287 NM_001162407 NP_001155879 NM_004071 NP_004062 NR_027855 NR_027856 NM_001024646
Function	Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates: SRSF1, SRSF3 and PTPN1. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells and adenovirus E1A pre-mRNA. {ECO:0000269|PubMed:10480872, ECO:0000269|PubMed:19168442}.
Subcellular Location	Nucleus.
Tissue Specificity	Endothelial cells. {ECO:0000269|PubMed:19168442}.
Top Pathways	Legionellosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CLK1 CRISPR/Cas9 KO Plasmid (h) - sc-402793 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CLK1 HDR Plasmid (h) - sc-402793-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CLK1 Double Nickase Plasmid (h) - sc-402793-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CLK1 Double Nickase Plasmid (h2) - sc-402793-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CLK1 CRISPR Activation Plasmid (h) - sc-402793-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CLK1 CRISPR Activation Plasmid (h2) - sc-402793-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

CLK1 Lentiviral Activation Particles (h) - sc-402793-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CLK1 Lentiviral Activation Particles (h2) - sc-402793-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

CLK1 siRNA (h) - sc-60404 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CLK1 shRNA Plasmid (h) - sc-60404-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

CLK1 shRNA (h) Lentiviral Particles - sc-60404-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU095081 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK0452 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0450 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0449 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0454 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0451 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0453 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN6239 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6239 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

CLK1 siRNA (Human) - CRH0854 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

CLK1 RNAi - H00001195-R03 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

CLK1 - MBS8237979 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human CLK1 (NM_004071.3) - SHH265405 from Creative biogene Category siRNA Species Reactivities Human

CLK1 shRNA Plasmid (Human) - CHH0854 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

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