| Gene Symbol | NHP2 |
|---|---|
| Entrez Gene | 55651 |
| Alt Symbol | DKCB2, NHP2P, NOLA2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | NHP2 ribonucleoprotein |
| Other Description | H/ACA ribonucleoprotein complex subunit 2|NHP2 ribonucleoprotein homolog|NHP2-like protein|nucleolar protein family A, member 2 (H/ACA small nucleolar RNPs)|snoRNP protein NHP2 |
| Swissprots | Q9NX24 A6NKY8 Q9P095 |
| Accessions | EAW53848 Q9NX24 AF161404 AAF28964 AF401217 AAL02173 AF401219 AAL02175 AJ293309 CAC08452 AK000486 BAA91198 BC000009 AAH00009 BC006387 AAH06387 BE797477 BG827491 BM913344 CR457238 CAG33519 NM_001034833 NP_001030005 NM_017838 NP_060308 |
| Function | Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. {ECO:0000269|PubMed:15044956}. |
| Subcellular Location | Nucleus, nucleolus. Nucleus, Cajal body. Note=Also localized to Cajal bodies (coiled bodies). |
| Tissue Specificity | Expressed in brain, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus. Also expressed at lower levels in the liver. {ECO:0000269|PubMed:12020816}. |
| Top Pathways | Ribosome biogenesis in eukaryotes |
NHP2 CRISPR/Cas9 KO Plasmid (h) - sc-408914 from Santa Cruz Biotechnology
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NHP2 HDR Plasmid (h) - sc-408914-HDR from Santa Cruz Biotechnology
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NHP2 Double Nickase Plasmid (h) - sc-408914-NIC from Santa Cruz Biotechnology
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NHP2 Double Nickase Plasmid (h2) - sc-408914-NIC-2 from Santa Cruz Biotechnology
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NHP2 CRISPR Activation Plasmid (h) - sc-408914-ACT from Santa Cruz Biotechnology
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NHP2 CRISPR Activation Plasmid (h2) - sc-408914-ACT-2 from Santa Cruz Biotechnology
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NHP2 Lentiviral Activation Particles (h) - sc-408914-LAC from Santa Cruz Biotechnology
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NHP2 Lentiviral Activation Particles (h2) - sc-408914-LAC-2 from Santa Cruz Biotechnology
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NHP2 siRNA (h) - sc-38300 from Santa Cruz Biotechnology
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NHP2 shRNA Plasmid (h) - sc-38300-SH from Santa Cruz Biotechnology
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NHP2 shRNA (h) Lentiviral Particles - sc-38300-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU108001 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15286 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15286 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02821 from Sigma-Aldrich
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NHP2 siRNA (Human) - CRJ0803 from Cohesion Biosciences
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shRNA set against Human NHP2 (NM_017838.3) - SHH352284 from Creative biogene
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shRNA set against Human NOLA2(NM_001034833.1) - SHR002428 from Creative biogene
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shRNA set against Human NOLA2(NM_017838.3) - SHR002670 from Creative biogene
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Human NHP2 siRNA - orb271304 from Biorbyt
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NHP2 shRNA Plasmid (Human) - CHJ0803 from Cohesion Biosciences
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NHP2 miRNA 3'UTR clone - MiUTR1H-06840 from Creative biogene
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NHP2 miRNA 3'UTR clone - MiUTR1H-06841 from Creative biogene
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