NHP2

Gene Symbol NHP2
Entrez Gene 55651
Alt Symbol DKCB2, NHP2P, NOLA2
Species Human
Gene Type protein-coding
Description NHP2 ribonucleoprotein
Other Description H/ACA ribonucleoprotein complex subunit 2|NHP2 ribonucleoprotein homolog|NHP2-like protein|nucleolar protein family A, member 2 (H/ACA small nucleolar RNPs)|snoRNP protein NHP2
Swissprots Q9NX24 A6NKY8 Q9P095
Accessions EAW53848 Q9NX24 AF161404 AAF28964 AF401217 AAL02173 AF401219 AAL02175 AJ293309 CAC08452 AK000486 BAA91198 BC000009 AAH00009 BC006387 AAH06387 BE797477 BG827491 BM913344 CR457238 CAG33519 NM_001034833 NP_001030005 NM_017838 NP_060308
Function Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme. {ECO:0000269|PubMed:15044956}.
Subcellular Location Nucleus, nucleolus. Nucleus, Cajal body. Note=Also localized to Cajal bodies (coiled bodies).
Tissue Specificity Expressed in brain, colon, heart, kidney, ovary, pancreas, placenta, prostate, skeletal muscle, small intestine, spleen, testis and thymus. Also expressed at lower levels in the liver. {ECO:0000269|PubMed:12020816}.
Top Pathways Ribosome biogenesis in eukaryotes

NHP2 (C-18) - sc-26988 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

NHP2 (H-9) - sc-398430 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
NHP2 (H-9): sc-398430. Western blot analysis of NHP2 expression in human spleen tissue extract.

NHP2 (H-107) - sc-366967 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
NHP2 (H-107): sc-366967. Western blot analysis of NHP2 expression in HeLa whole cell lysate.

NHP2 (M-15) - sc-26991 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-NHP2 antibody - ab150918 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-NHP2 antibody (ab150918) at 1/100 dilutionLane 1 : NIH-3T3 cell lysate (Mouse embryonic cells)Lane 2 : NBT-II cell lysate (Rat Wistar bladder tumour cells)

Anti-NHP2 antibody [EPR12404] - ab180498 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12404
All lanes : Anti-NHP2 antibody [EPR12404] (ab180498) at 1/2000 dilutionLane 1 : K562 lysateLane 2 : Jurkat lysateLane 3 : Caco 2 lysateLane 4 : SH-SY5Y lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/1000 dilution

Anti-NHP2 antibody [EPR12410] - ab172481 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR12410
All lanes : Anti-NHP2 antibody [EPR12410] (ab172481) at 1/1000 dilutionLane 1 : K562 cell lysateLane 2 : Jurkat cell lysateLane 3 : Caco 2 cell lysateLane 4 : SH-SY5Y cell lysateLysates/proteins at 10 µg per lane.

Anti-NHP2 antibody - C-terminal - ab199859 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-NHP2 antibody - C-terminal (ab199859) at 1/1000 dilutionLane 1 : HeLa total cell extractsLane 2 : Jurkat total cell extracts

Anti-NOLA2 Antibody - LS-C334440 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using NHP2 antibody.

NHP2 Antibody - NBP2-38626 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

NHP2 Antibody - NBP2-13656 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: NHP2 Antibody [NBP2-13656] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells). Lane 2: NBT-II cell lysate (Rat Wistar bladder tumor cells).

NHP2 Antibody - 45810002 from Novus Biologicals

Prices $299.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ELISA: NHP2 Antibody [45810002]

Anti-NHP2 antibody produced in rabbit - HPA044171 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-NHP2:<B>Cat. No. HPA044171</B>: Immunohistochemical staining of human colon shows moderate cytoplasmic and nucleolar positivity in glandular cells.

Anti-NHP2 (61-75) antibody produced in rabbit - SAB1102370 from Sigma-Aldrich

Prices $298.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells overexpressing human NHP2 was separated on SDS-PAGE, blotted with Anti-NHP2 (61-75) (<B>Cat. No. SAB1102370</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate. <BR/><B>Lanes</B><BR/>1. Antibody dilution 1:250

NHP2 Polyclonal Antibody - A5991 from ABclonal

Prices $130.00, $220.00, $380.00
Sizes 50 µl, 100 µl, 200 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using NHP2 antibody.

NHP2 antibody - 70R-18876 from Fitzgerald

Prices $375.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

NHP2 Antibody - abx004601 from Abbexa

Host Rabbit
Clonality Polyclonal

NOLA2 antibody - 15128-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded Prostate cancer using 15128-1-AP(NHP2 Antibody) at Dilution 1:100 (under 10x lens)

Anti-NHP2, Polyclonal Antibody - 25-A5991 from ARP American Research Products

Prices $279.00, $549.00
Sizes 50 µg, 200 µg
Host Rabbit
Clonality Polyclonal

NHP2 antibody - STJ27787 from St John's Laboratory Ltd

Host Rabbit
Clonality Polyclonal

NHP2 antibody - 15128-1-AP from Proteintech Group

Prices $279.00
Sizes con: 23 μg/150μl
Host Rabbit
Clonality Polyclonal
A375 cells were subjected to SDS PAGE followed by western blot with 15128-1-AP(NHP2 antibody) at dilution of 1:300

NHP2 - A5991 from NeoScientific

Prices $480.00
Sizes 200 µg
Host Rabbit
Clonality Polyclonal

Anti-NHP2 (aa 81-150) polyclonal antibody - DPABH-03067 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-NHP2 monoclonal antibody, clone FQS23521 - DCABH-5759 from Creative Diagnostics

Host Rabbit
Clonality Monoclonal
Clone FQS23521

Anti-NHP2 monoclonal antibody, clone FQS23515 - DCABH-6830 from Creative Diagnostics

Host Rabbit
Clonality Monoclonal
Clone FQS23515
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